Principal Scientist - Medicinal Chemistry

1001 Amgen Inc.; South San Francisco (CA); On-site; USD 165,000 - 224,000; Full time

Benefits offered by this job

Flexible work models

Remote/hybrid opportunities

Competitive benefits

Job summary

Amgen Inc. in South San Francisco seeks a Principal Scientist in Medicinal Chemistry to design, synthesize, and purify novel compounds for potential clinical development. This onsite role participates in Amgen’s IPP PROTAC initiatives and advances targets through innovative chemistry and collaboration.

The role involves leading medicinal chemistry teams, publishing results, and mentoring researchers, with a competitive salary and a strong emphasis on collaboration and scientific impact.

Qualifications

• PhD with multiple years of scientific experience or equivalent combination toward drug discovery.
• Strong background in organic synthesis, medicinal chemistry, and related disciplines.
• Proven ability to lead medicinal chemistry projects and deliver clinical candidates.

Responsibilities

• Devise and implement state-of-the-art scientific research through laboratory experiments and project planning with timelines and milestones.
• Review, analyze, and interpret data; regularly update and document results; collaborate with scientists and stay current with literature and technology development.
• Advise supervisors and colleagues, participate in meetings, contribute to publications/patents, and mentor research staff.

Skills

Organic synthesis

Medicinal chemistry

Team leadership

Communication

Education

Doctorate degree in Chemistry

Master's degree

Bachelor's degree

Job description

Career Category Scientific Job Description

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist - Medicinal Chemistry

What you will do Let’s do this. Let’s change the world. In this vital role you will part of an innovative Medicinal Chemistry group, with responsibilities including (but not limited to) the design, synthesis, and purification of novel compounds for potential clinical drug development. This will also include the opportunity to work within Amgen’s Induced Proximity Platform (IPP), which is focused on novel and innovative approaches to modulate intractable targets in diseases using the emerging PROTAC modality. This is an onsite laboratory position at our South San Francisco site.

Responsibilities

Devise and implement state of the art scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results and necessary resources. Review, analyze, and interpret scientific data and results; providing regular updates, documentation, and/or communication on project results; collaborating with other scientists and keeping current with field of expertise, including literature and technology development. Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international meetings, providing scientific results that support the generation of publications or patents, and mentoring research associates and laboratory assistants.

What we expect of you

Basic Qualifications

• Doctorate degree and 2 years of scientific experience or Master’s degree and 5 years of scientific experience or Bachelor’s degree and 7 years of scientific experience

Preferred Qualifications

• Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry
• Experience leading medicinal chemistry teams and delivering candidates for clinical development
• Extensive track record of consistent and successful drug discovery accomplishments (e.g. patent inventor-ship, conference presentations, and peer-reviewed publications)
• Deep understanding of drug discovery and relevant drug discovery disciplines (e.g. chemistry, biology, safety, PKDM, etc.)
• Expert in modern medicinal and synthetic chemistry approaches
• Excellent collaboration and communication skills (both written and oral)

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

Benefits

• A Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Salary

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Salary Range 165,307.15USD -223,650.85 USD

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Equal Opportunity Employer

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Corporate Overview

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.