Principal Scientist, LCMS

Kelly Services; Malvern (Chester County); On-site; USD 140,000 - 150,000; Full time

Benefits offered by this job

Medical benefits

PTO & holidays

401K

Relocation assistance

Job summary

Kelly Science & Clinical seeks a Principal Scientist to lead LC-MS-based quantitative bioanalysis for large molecule therapeutics at our Malvern, PA client site. The role emphasizes method development, validation, and application in nonclinical and clinical studies.

You will lead programs, mentor scientists, present findings to clients, and help expand HRMS capabilities. Eligible for medical benefits, PTO, holidays, and 401K; relocation support available for non-local candidates.

Qualifications

• PhD with 10+ years in bioanalysis (GLP).
• Experience in oligonucleotide, protein or antibody-drug conjugate (ADC) bioanalysis.
• Knowledge of LBA and LC-MS for large molecule quantitation.
• Proven ability to lead scientific programs and client interactions.

Responsibilities

• Lead LC-MS method development and validation programs.
• Provide technical oversight of complex bioanalytical data for PK/TK studies.
• Direct multiple client programs and study design strategy.
• Drive innovation and automation in LC-MS workflows.
• Collaborate with QA, regulatory, and project management teams.
• Author study plans, validation protocols, reports, and SOPs.
• Mentor and train junior scientists.

Skills

PhD + 10+ yrs

GLP bioanalysis

LC-MS method development

HRMS experience

Leadership

Bioanalytical validation

Education

PhD in life sciences

MS with 15+ yrs

Tools

Triple quadrupole MS

HRMS platforms

LC-MS workflows

Bioanalytical LC-MS

Job description

Principal Scientist, LCMS Quantitative Bioanalysis

Kelly Science and Clinical has an opening for a Principal Scientist for an engagement at one of our leading pharmaceutical CRO clients in Malvern, PA. The role is eligible for medical benefits, paid time off including vacation (PTO), and holidays, and 401K. If you’re passionate about bringing the latest scientific discoveries to life and are ready to take the next step in your career,

Schedule : Mon-Fri, 8AM-5PM

Location : Malvern, PA

Duration : Direct Hire

Compensation : $140,000-$150,000

Relo support for non-local candidate

Position Summary

We are seeking a highly motivated and experienced Principal Scientist to provide scientific leadership in the development, validation, and application of LC-MS-based quantitative bioanalytical methods supporting large molecule therapeutics. This role will focus on method development and method validation for quantitative analysis of large molecule modalities supporting nonclinical and clinical studies. Modalities include proteins, peptides, oligonucleotides, and drug conjugates. The successful candidate will serve as a technical expert in mass spectrometry leading complex projects, representing the Company in client interactions and troubleshooting methods. Additional expertise in high-resolution mass spectrometry (HRMS) is highly desirable.

The Principal Scientist will play a critical role in expanding our large molecule bioanalytical capabilities and supporting the successful development of next-generation therapeutics, including biologics, oligonucleotides, and antibody-drug conjugates. This individual will contribute to scientific strategy, technical excellence, and the continued growth of the organization

Key Responsibilities

• Serve as a scientific leader for method development and validation of LC-MS-based quantitative bioanalysis programs supporting preclinical and clinical studies. Experience in GLP method validation is a must.
• Design, develop, optimize, validate, and troubleshoot quantitative bioanalytical methods for large molecule therapeutics in biological matrices.
• Provide technical oversight and interpretation of complex bioanalytical data to support pharmacokinetic (PK), toxicokinetic (TK), and biomarker studies.
• Lead multiple client programs simultaneously and serve as a scientific point of contact for study design, strategy, and data interpretation.
• Drive innovation and implementation of advanced LC-MS technologies, workflows, and automation strategies.
• Collaborate cross-functionally with project management, laboratory operations, quality assurance, and regulatory teams to ensure successful study execution.
• Author and review study plans, validation protocols, reports, regulatory submissions, scientific publications, and standard operating procedures.
• Evaluate emerging technologies and contribute to strategic expansion of bioanalytical capabilities.
• Present scientific findings to clients, senior leadership, and at external scientific conferences.
• May have a small group of scientists reporting directly to this role for scientific training, mentorship and problem solving.

Qualifications

Required

• PhD with 10+yrs of experience, may consider MS with 15+yrs of experience
• Extensive experience in development and validation of oligonucleotide, protein or antibody-drug conjugate (ADC) therapeutics for nonclinical and clinical bioanalysis in a GLP environment. Deep experience in one of the listed areas is sufficient, but preference given for experience in more than one area.
• Knowledge of hybrid ligand-binding assay (LBA) and LC-MS approaches for large molecule quantitation.
• Hands‑on experience with triple quadrupole mass spectrometry platforms and quantitative LC‑MS workflows.
• Proven ability to lead scientific programs.
• Strong knowledge of bioanalytical method development, validation, and regulatory guidance (FDA, EMA, ICH, M10) for supporting clinical bioanalysis programs.
• Excellent communication, problem‑solving, and client‑facing skills.

Preferred

• Experience with high-resolution mass spectrometry (HRMS) platforms such as Orbitrap or QTOF systems.
• Experience in a contract research organization (CRO) environment or as a scientific expert in pharma.
• Experience with representing the LC‑MS discipline to the external scientific community or clients.
• Track record of scientific publications, conference presentations, client interaction and engagement or technology development initiatives.
• Ability to mentor and develop scientist

Please note: The following benefits reflect Kelly's general offerings. Eligibility may vary by assignment, location, and job type. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short‑term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here (https://www.mykelly.com/help-support-working-with-kelly-us/#Benefits) for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

Why Kelly ® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals—it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

Work changes everything. And at Kelly, we’re obsessed with where it can take you. To us, it’s about more than simply accepting your next job opportunity. It’s the fuel that powers every next step of your life. It’s the ripple effect that changes and improves everything for your family, your community, and the world. Which is why, here at Kelly, we are dedicated to providing you with limitless opportunities to enrich your life—just ask the 300,000 people we employ each year.

Kelly is committed to providing equal employment opportunities to all qualified employees and applicants regardless of race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or any other legally protected status, and we take affirmative action to recruit, employ, and advance qualified individuals with disabilities and protected veterans in the workforce. Requests for accommodation related to our application process can be directed to the Kelly Human Resource Knowledge Center. Kelly complies with the requirements of California’s state and local Fair Chance laws. A conviction does not automatically bar individuals from employment. Kelly participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.

Kelly may use AI-powered tools during the recruitment and hiring process. For full details, including how Kelly uses AI, your rights, and how to request a reasonable accommodation, visit the Recruitment Artificial Intelligence Notice (https://www.kellyservices.com/hubfs/myKelly/Resources/Employment_Policies/Recruitment-Artificial