Principal Scientist - LC-MS in Carlsbad

Energy Jobline ZR; Carlsbad (CA); On-site; USD 140,000 - 165,000; Full time

Benefits offered by this job

Relocation assistance

Health/Dental/Vision insurance

401k plan

Job summary

Energy Jobline ZR in Carlsbad, CA is seeking a Principal Scientist – LC-MS to lead analytical development for drug substance and finished products, with hands-on lab work and strong project leadership.

The role emphasizes LC-MS method development and validation, GMP compliance, and regulatory contributions (INDs/CMC). Relocation assistance and comprehensive benefits are offered.

Qualifications

• PhD with 3+ years or BS/MS with 5+ years in industry.
• Strong hands-on LC-MS experience, including method development and validation.
• Experience in GMP-regulated pharma/biotech environments.
• Understanding of ICH/FDA guidelines; phase-appropriate analytical methods.
• Experience with oligonucleotides highly desirable; proteins/peptides of interest.
• Strong project management and communication skills.

Responsibilities

• Lead analytical development and QC activities supporting drug substance and finished drug products.
• Develop, optimize, and validate LC-MS and other analytical methods.
• Manage internal projects and external analytical partnerships.
• Oversee release testing, stability studies, and analytical investigations.
• Contribute to regulatory submissions including INDs, IMPDs, and CMC documentation.
• Work across R&D and routine QC activities with hands-on laboratory involvement.

Skills

Project management

Communication

Problem solving

Education

PhD in a relevant field

BS/MS with 5+ years','weight":7}],

Tools

LC-MS

LC-MS method development

Job description

Principal Scientist – LC-MS

Carlsbad, CA

An exciting opportunity for an experienced Analytical Chemist to join an innovative biopharmaceutical organization developing novel therapeutics.

This position offers an excellent blend of hands-on analytical science, project leadership, and regulatory involvement, with the opportunity to take ownership of projects and potentially build a team.

Primary Responsibilities

• Lead analytical development and QC activities supporting drug substance and finished drug products.
• Develop, optimize, and validate LC-MS and other analytical methods.
• Manage internal projects and external analytical partnerships.
• Oversee release testing, stability studies, and analytical investigations.
• Contribute to regulatory submissions, including INDs, IMPDs, and CMC documentation.
• Work across both R&D and routine QC activities, retaining significant hands-on laboratory involvement.

Primary Qualifications

• PhD with 3+ years or BS/MS with 5+ years of relevant industry experience.
• Strong hands-on LC-MS experience, including method development and validation.
• Experience working in a GMP-regulated pharmaceutical or biotechnology environment.
• Understanding of ICH/FDA guidelines and phase-appropriate analytical methods.
• Experience with oligonucleotides highly desirable; proteins and peptides also of interest.
• Strong project management, communication, and problem-solving skills.

Salary / Benefits

• $140-165K annual base salary (or MORE!) for qualified candidates
• Help with relocation
• Excellent benefits inc. Health/Dental/Vision, 401k with march, etc.