Principal Scientist LC-MS

Actox; Carlsbad (CA); On-site; USD 140,000 - 165,000; Full time

Benefits offered by this job

Relocation assistance

Health benefits

401k plan

Dental/Vision coverage

Job summary

Actox in Carlsbad, CA is seeking a Principal Scientist – LC-MS to lead analytical development for drug substances and finished products, with hands-on LC-MS method development and validation. You will guide internal projects, manage external partnerships, and contribute to regulatory filings while maintaining strong hands-on lab involvement across R&D and QC.

The ideal candidate has a PhD with 3+ years or BS/MS with 5+ years in a GMP environment, plus experience in ICH/FDA guidelines and

Qualifications

• PhD with 3+ years in industry or BS/MS with 5+ years of relevant experience.
• Strong hands-on LC-MS experience, including method development and validation.
• Experience in GMP-regulated pharmaceutical/biotech environment.
• Understanding of ICH/FDA guidelines and phase-appropriate analytical methods.
• Experience with oligonucleotides desirable; proteins/peptides also of interest.
• Strong project management, communication, and problem-solving skills.

Responsibilities

• Lead analytical development and QC activities supporting drug substance and finished drug products.
• Develop, optimize, and validate LC-MS and other analytical methods.
• Manage internal projects and external analytical partnerships.
• Oversee release testing, stability studies, and analytical investigations.
• Contribute to regulatory submissions, including INDs, IMPDs, and CMC documentation.
• Work across R&D and routine QC with hands-on lab involvement.

Skills

LC-MS experience

Project management

Communication

Problem solving

Education

PhD with 3+ years

BS/MS with 5+ years

Tools

LC-MS instrumentation

Job description

Principal Scientist – LC-MS
Carlsbad, CA

An exciting opportunity for an experienced Analytical Chemist to join an innovative biopharmaceutical organization developing novel therapeutics.

This position offers an excellent blend of hands‑on analytical science, project leadership, and regulatory involvement, with the opportunity to take ownership of projects and potentially build a team.

Primary Responsibilities

• Lead analytical development and QC activities supporting drug substance and finished drug products.
• Develop, optimize, and validate LC-MS and other analytical methods.
• Manage internal projects and external analytical partnerships.
• Oversee release testing, stability studies, and analytical investigations.
• Contribute to regulatory submissions, including INDs, IMPDs, and CMC documentation.
• Work across both R&D and routine QC activities, retaining significant hands‑on laboratory involvement.

Candidate Qualifications

• PhD with 3+ years or BS/MS with 5+ years of relevant industry experience.
• Strong hands‑on LC-MS experience, including method development and validation.
• Experience working in a GMP-regulated pharmaceutical or biotechnology environment.
• Understanding of ICH/FDA guidelines and phase‑appropriate analytical methods.
• Experience with oligonucleotides highly desirable; proteins and peptides also of interest.
• Strong project management, communication, and problem‑solving skills.

Salary:

• $140-165K annual base salary (or MORE!) for qualified candidates
• Help with relocation
• Excellent benefits inc. Health/Dental/Vision, 401k with march, etc.

Reference#: VRS2435

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