Principal Scientist (Lab Head), Mass Spectrometry Based Biomarkers

Boehringer Ingelheim; Ridgefield (CT); On-site; USD 141,000 - 211,000; Full time

Job summary

Boehringer Ingelheim is seeking a Principal Scientist to lead Mass Spectrometry-based Biomarker efforts within the Drug Discovery Sciences department. You will influence decision-making in global project teams and advance next-generation biomarker capabilities in a collaborative research setting.

The role combines scientific excellence, strategy, and people leadership to push innovative drug candidates toward clinical development, with a focus on biomarker-driven decisions and impactful

Qualifications

• PhD required with 5+ years in preclinical drug discovery with leadership responsibilities.
• Experience leading employees and projects is required (1–3 years).
• Strong biomarker translational science knowledge relevant to drug discovery.
• Deep mass spec expertise with small molecule quantitative workflows.
• Excellent stakeholder management and communication skills.

Responsibilities

• Review BM discovery & quantitation requests and align with project partners.
• Lead MS Biomarker function representation in cross-functional teams.
• Design, execute, and analyze MS-based experiments including targeted quantitation.
• Work with cutting-edge MS platforms and analysis software.
• Drive innovations and lead development of global team strategies and initiatives.
• Mentor and develop scientists in a collaborative environment.

Skills

Biomarker expertise

Leadership

Mass spectrometry

Data interpretation

Presentation skills

Education

PhD in biochemistry/pharmacology or related

Tools

Orbitrap

timsTOF

QQQ

Proteomics software

Job description

We are seeking a highly motivated Principal Scientist to join our global Mass Spectrometry-based Biomarker team within the Drug Discovery Sciences (DDS) department. You’ll work at the cutting edge of drug discovery - shaping breakthrough therapies and making an immediate impact.

You will work in global multidisciplinary project teams generating high-impact results that directly impact decision-making and help advance innovative drug candidates toward clinical development. This opportunity combines scientific excellence, strategic thinking, and people leadership with the advancement of next‑generation biomarker capabilities in a collaborative global research environment.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the company’s success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work‑life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Description

We are seeking a highly motivated Principal Scientist to join our global Mass Spectrometry-based Biomarker team within the Drug Discovery Sciences (DDS) department. You’ll work at the cutting edge of drug discovery - shaping breakthrough therapies and making an immediate impact.

You will work in global multidisciplinary project teams generating high-impact results that directly impact decision-making and help advance innovative drug candidates toward clinical development. This opportunity combines scientific excellence, strategic thinking, and people leadership with the advancement of next‑generation biomarker capabilities in a collaborative global research environment.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the company’s success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work‑life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• In this role, you will review requests for BM discovery & quantitation, decide on resources & align the purpose and path-forward with our partners in project teams
• Act as a scientific leader and key representative of the MS Biomarker function in cross-functional project teams, contributing to projects in discovery research.
• Lead the design, execution, and analysis of mass spectrometry-based experiments, including small molecules, protein Biomarker quantitation and in vitro proteomics.
• Expertise in operating cutting-edge mass spectrometry platforms (Orbitrap, Bruker timsTOF, Sciex QQQ.) and expert understanding of respective analysis software.
• Hands‑on experience with establishing and implementing mass spectrometry based targeted quantitation methods, developing and optimizing innovative analysis workflows.
• Independently drive innovations, lead the development and implementation of global team strategies/initiatives to advance projects.
• Lead, mentor and develop scientists within a high‑performing and collaborative research environment.

Requirements

• PhD in biochemistry, pharmacology or related scientific discipline 5 years or more of experience in preclinical drug discovery, including (matrix) leadership responsibilities
• One (1) to three (3) years´ experience leading employees and projects is required.
• Track record as a scientific representative in discovery projects, with the ability to influence project direction in an industry setting
• Strong understanding of biomarkers, translational sciences, biochemical mechanisms, and pharmacological principles relevant to drug discovery
• Deep expertise in mass spectrometry-based applications, with strong experience with small molecule quantitative/targeted workflows. Demonstrated ability to solve complex drug discovery challenges
• Analytical mindset with experience in sample preparation from cells and tissues for LC‑MS analyses
• Solid understanding of proteomics approaches for cell pharmacology relevant to drug discovery
• Forward‑looking mindset, with a passion for advancing mass spectrometry-based applications for better impact in drug discovery
• Excellent presentation skills, stakeholder management and ability to present concepts outside of expertise area

Eligibility Requirements

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post‑offer physical (if required)
• Must be 18 years of age or older

Compensation Data

This position offers a base salary typically between $140,800.00 and $211,200.00 USD. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here .

Our Company

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long‑term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at www.boehringer-ingelheim.com.

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com