Principal Scientist, High-Content Imaging

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 150,000 - 190,000; Full time

Job summary

Johnson & Johnson's Innovative Medicine division seeks a Principal Scientist in High-Content Imaging based in Spring House, PA. You will lead the development and deployment of complex imaging assays across immunology, neuroscience, and oncology programs, driving technical leadership and data quality.

You will collaborate with internal teams, CROs and external partners to translate imaging readouts into actionable biological insights, while advancing drug discovery workflows with robust, scalable

Qualifications

• PhD in Biochemistry, Systems Biology, or related field.
• Minimum 4 years industry experience with high-content imaging, assay development and computational image analysis.
• Excellent communication and collaborative skills.

Responsibilities

• Develop, validate, and deploy high-content imaging assays across cell models and tissues.
• Establish workflows, troubleshoot, and optimize protocols for imaging.
• Collaborate with internal teams, CROs and partners to generate data and translate readouts into biological insights.

Skills

High-content imaging

Assay development

Computational image analysis

Scientific communication

Education

PhD in Biochemistry

PhD in Systems Biology

Tools

R

Python

AI/ML concepts

Job description

Role

Principal Scientist in High-Content Imaging within Johnson & Johnson's Innovative Medicine division, focusing on advancing therapeutic discovery in Immunology, Neuroscience, and Oncology.

Responsibilities include developing, validating, and deploying complex high-content imaging assays across diverse cell models and tissues, establishing workflows, troubleshooting, and optimizing protocols. The role involves collaborating with internal teams, CROs, and external partners to generate high-quality data, support data analysis pipelines, and translate imaging readouts into biological insights.

Qualifications

Ph.D. in Biochemistry, Systems Biology, or related field; minimum of 4 years industry experience with proven expertise in high-content imaging, assay development, and computational image analysis; excellent communication and collaborative skills.

Preferred

Experience with complex cell/tissue models, external collaborations, data integration, and programming in R/Python; familiarity with AI/ML approaches is a plus.

High-value specifics include application across disease-relevant models in Immunology, Neuroscience, and Oncology, with a focus on drug discovery workflows. The position is based in Spring House, PA, with an emphasis on technical leadership and innovation in high-dimensional biological assays.