Principal Scientist/Director, Bioanalytical Chemistry

VidaVinci, Inc.; Cambridge (MA); On-site; USD 88,000 - 122,000; Full time

Job summary

VidaVinci, Inc. seeks a Principal Scientist/Director in Bioanalytical Chemistry to lead innovative assay developments at their Cambridge site. This role requires expertise in mass spectrometry, analytical chemistry, and a collaborative spirit to advance bioanalytical initiatives within the company. Candidates with exceptional leadership skills and a strong scientific background will thrive in this dynamic environment.

Qualifications

• 5-7+ years of industry experience.
• High proficiency in mass spectrometry operations.
• Excellent written and documentation skills.

Responsibilities

• Develop and implement state-of-the-art mass spectrometry analytics.
• Maintain mass spectrometry instrumentation and software.
• Collaborate with data teams to generate and interpret data.

Skills

Mass Spectrometry

Analytical Chemistry

Assay Development

Data Analysis

Collaboration

Education

Ph.D. in Analytical Chemistry or related field

M.S. in relevant analytical experience

B.S. with 8+ years experience

Job description

Principal Scientist/Director, Bioanalytical Chemistry

Principal Scientist/Director, Bioanalytical Chemistry

Direct message the job poster from VidaVinci, Inc.

HR Advisor | HR Business Partner | Fractional HR Leader | Compensation and Benefits | Ad hoc project work |

Overview

We are seeking an experienced Bioanalytical Scientist with outstanding expertise in Mass Spectrometry and bioanalytical assay development to lead a dedicated team at our Cambridge Site. In this role, you will pioneer and expand upon VidaVinci’s state-of-the-art assay and analytical platforms, driving innovation and scientific rigor across our bioanalytical initiatives. The ideal candidate will be highly motivated, possess a creative and exploratory mindset, and have expertise in mass spectrometry–based analysis of both small molecules and peptides. Experience with Orbitrap Thermo-Fisher mass spectrometers instrumentation is a plus. The candidate should also have extensive knowledge of analytical software for processing and interpretation of mass spectrometry data; familiarity with programming languages and database software is a plus.

Responsibilities

• Develop and implement state-of-the-art mass spectrometry-based analytics techniques to identify and characterize peptides and protein ligand complexes.
• Develop, or oversee the outsourced development of, customized software for mass spectrometric analyses tailored to the specific demands of VidaVinci.
• Maintain all mass spectrometry instrumentation and the associated analytical software.
• Design, optimize, and execute technical development experiments to push highly multiplexed, isobaric resolving, de-novo peptide sequencing capabilities.
• Design, optimize, and execute MS-based assays to characterize peptide interactions with targets and off-target proteins (affinity selection/purification, CETSA/TPP) to support SAR investigations.
• Design, optimize, and implement additional multiplexed drug characterization assays. Utilization of qualitative methods where appropriate for differentiation of isomeric peptide, coupled with semi-quantitative methods to deliver on characterization needs.
• Collaborate with data teams to enable the generation and interpretation of data.
• Work with collaborators, both internal and external, to effectively generate data and lead in assay development and execution to progress multiple targeted programs.
• Communicate results to the company’s senior leadership.
• Analyze experimental data and present it to a multifunctional team.
• Proactively evaluate new technologies, be versed with current literature, and implement new methods into the mass spectrometry assay/analytical pipeline as necessary.

Required Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Chemical Biology, or a related field with 5-7+ years of industry experience; OR M.S. with 6+ years of relevant analytical experience; OR B.S. with 8+ years of relevant analytical experience.
• High proficiency in mass spectrometry operations and theory required.
• Hands-on experience on MS-based bio-analytical chemistry assay development.
• Experience in sample cleanup strategies employed in LCMS workflows.
• In depth ability to troubleshoot LCMS systems and advise cross-functional teams about input compatibility.
• Knowledge and appreciation of laboratory safety procedures.
• Ability to thrive in a fast-paced dynamic team environment and be inspired to develop and apply new technologies to advance projects efficiently.
• Excellent written, organizational, analysis, and documentation skills.
• Ability to communicate progress effectively with colleagues across several scientific disciplines.
• Good working knowledge of adjacent domain(s) of drug discovery.

Preferred Qualifications

• Experience with Thermo MS software, their line of Tribrid mass spectrometers, and their routine maintenance. Ability to navigate MS method architectures, weigh the pros and cons of different scan setups, and enable sufficient data quality while enabling high sample coverage.
• Experience handling large-scale quantitative or semi-quantitative analytical chemistry assays.
• Experience scaling laboratory operations to enable greater sample throughput and experience scaling (or collaborating with people who scale) data analysis techniques to match demand.
• Hands-on experience with classical proteomics protein/peptide characterization workflows (peptide mapping, de-novo peptide sequencing, target interaction screening (ALIS/ASMS/APMS), and broad off-target counter-screening techniques (ex: CETSA/TPM))
• Experience developing and implementing native-MS methods for intact protein complex characterization.
• Experience with electron transfer dissociation (ETD) as a fragmentation technique is preferred. A strong ability to evaluate the advantages and limitations of various fragmentation technologies is highly valued.
• Experience mentoring and training junior scientists.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research

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