Principal Scientist, Computational Design (Hybrid/Remote)

Bristol Myers Squibb; San Diego (CA); On-site; USD 157,000 - 190,000; Full time

Job summary

Bristol Myers Squibb in San Diego seeks a Principal Scientist in Computational Sciences to lead the Small Molecule Computational Design efforts. You will apply structure-based design, cheminformatics, and machine learning to advance discovery programs and generate actionable molecular designs.

You will collaborate with multidisciplinary teams, mentor colleagues, publish work, and help translate data into design decisions while driving program strategy within our Computational Sciences group.

Qualifications

• Ph.D. with 4+ years of academic or industry experience, Master’s degree with 6+ years of experience, Bachelor’s degree with 8+ years of experience in computational chemistry, cheminformatics, computational biophysics, chemistry, or a related discipline.
• Strong history of directly impacting small molecule discovery programs in biotech or pharmaceutical industry, with a solid working knowledge of medicinal chemistry principles.
• Demonstrated hands-on depth across both computer-aided drug design and cheminformatics/machine learning.
• Experience with targeted protein degradation, molecular glues, or other induced-proximity modalities is preferred.
• Experience applying computational methods to diverse biological targets and modalities.
• Excellent communication and collaborative mindset in multidisciplinary teams.
• Track record of publications in peer-reviewed journals.

Responsibilities

• Serve independently as the computational scientist on Protein Homeostasis project teams, delivering computational objectives.
• Design, prioritize, and triage degrader and molecular glue chemical matter with multi-parameter optimization.
• Develop, validate, and deploy predictive models and cheminformatics workflows and drive their adoption.
• Integrate structural information with large-scale data analysis to deepen SAR insight and shape strategy.
• Curate and steward chemical and biological data resources and tooling for reproducibility.
• Provide scientific leadership and take calculated risks to test innovative approaches.
• Mentor colleagues and enhance internal and external scientific visibility through publications and presentations.

Skills

Computational chemistry

Cheminformatics

Machine learning

Education

Ph.D. with 4+ years

Master’s with 6+ years

Bachelor’s with 8+ years

Job description

Bristol Myers Squibb in San Diego seeks a Principal Scientist in Computational Sciences to lead the Small Molecule Computational Design efforts. You will apply structure-based design, cheminformatics, and machine learning to advance discovery programs and generate actionable molecular designs.

You will collaborate with multidisciplinary teams, mentor colleagues, publish work, and help translate data into design decisions while driving program strategy within our Computational Sciences group.