Principal Scientist, Biophysicist

Novartis; South Dakota; On-site; USD 108,500 - 222,300; Full time

Job summary

Novartis in La Jolla, CA, seeks a Principal Scientist I/II with deep biophysical assay experience to drive high-throughput screening and automation efforts on-site. The role emphasizes collaboration across research teams, data interpretation, and advancing assay technologies.

Ideal candidates hold a Ph.D. in a relevant field with 2+ years of industrial experience and are skilled in designing and troubleshooting biophysical assays while delivering robust data and publications.

Qualifications

• Ph.D. required in Biophysics, Biochemistry, Bioengineering or related field; 2+ years of industrial experience preferred.
• Deep expertise in designing, validating, executing and troubleshooting biophysical assays.
• Ability to manage multiple projects independently and adapt to changing priorities.
• Interest in adopting new technologies and driving workflow improvements.
• Strong communication and teamwork skills; able to present data effectively.

Responsibilities

• Design, develop and optimize biophysical assays (SPR, BLI) for small molecule characterization.
• Execute routine assays to define structure–activity relationships.
• Implement and manage automation to increase throughput and data quality.
• Collaborate with cross-functional teams to integrate new technologies and workflows.
• Analyze and present scientific data to internal and external stakeholders.
• Maintain thorough lab records and contribute to reports/publications.

Skills

Biophysical assays

SPR/BLI techniques

High-throughput screening

Project management

Cross-functional collaboration

Analytical troubleshooting

Education

Ph.D. in Biophysics/Biochemistry/Bioengineering

Tools

Laboratory automation platforms

Liquid handling systems

Electronic laboratory notebooks

Job description

Summary

We are seeking a highly motivated and experienced Principal Scientist / Biophysicist to join our dynamic team in La Jolla, CA. You will work on-site full-time and bring deep expertise in biophysical assay development and high-throughput screening. If you have a passion for advancing scientific discovery and thrive in a fast‑paced, collaborative, and cross‑disciplinary environment, we encourage you to apply.

About The Role

Internal Job Title: Principal Scientist I/Principal Scientist II
Position Location: onsite, La Jolla, CA

Key Responsibilities

• Design, develop, and optimize biophysical assays (e.g., SPR, BLI) for characterization of small molecules.
• Execute routine assays for defining structure‑activity relationships.
• Implement and manage automation solutions to enhance assay throughput and data quality.
• Collaborate with cross‑functional teams to integrate new technologies and workflows into ongoing research projects.
• Analyze, interpret, and present scientific data to internal and external stakeholders.
• Maintain detailed laboratory records, contribute to the preparation of research reports and publications, and represent the team through internal presentations.

Essential Requirements

• Ph.D. (post‑doc preferred), in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or a related field), with 2+ years of industrial experience in drug discovery
• Deep expertise in designing, validating, executing and troubleshooting biophysical assays.
• Ability to manage multiple projects independently and adapt to evolving research priorities.
• Ability to innovate, keep up with the expanding field, recommend and bring in new technologies.
• Strong analytical, troubleshooting, and problem‑solving skills.
• Excellent communication and teamwork abilities.

Desirable Requirements

• Experience in integrating novel or emerging technologies into high‑throughput screening workflows.
• Familiarity with data analysis software and electronic laboratory management systems.
• Hands‑on experience with laboratory automation platforms and liquid handling systems.

Salary and Compensation

The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

Benefits

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time‑off package including vacation, personal days, holidays and other leaves.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e‑mail to [e-mail] or call +1(877)395‑2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.