Principal Scientist, AOC Analytics & Oligonucleotide Conjugates
Atrium Therapeutics
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Descrizione del lavoro
Atrium Therapeutics seeks an experienced Principal Scientist to build and lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) delivering siRNA to cardiomyocytes. You will develop phase-appropriate analytical methods for drug substance, product, and intermediates, supporting IND-enabling and early clinical programs.
The role is lab-based, partnering with Biology, Developmental Sciences, CDMOs, and contract testing labs to establish analytical excellence within Chemistry
Competenze
- Ph.D. in analytical chemistry, biochemistry, chemistry or related field with 8+ years in industry.
- Demonstrated analytical leadership on AOC/ADC/oligonucleotide conjugate programs through IND or later.
- Expert hands-on in HPLC/UHPLC and LC-MS of proteins and/or oligonucleotides, incl. data processing and deconvolution.
Mansioni
- Lead efforts to build internal analytical capabilities and lab infrastructure.
- Develop, qualify, and transfer analytical methods for AOCs and oligonucleotide intermediates.
Conoscenze
Formazione
Strumenti
Descrizione del lavoro
Atrium Therapeutics seeks an experienced Principal Scientist to build and lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) delivering siRNA to cardiomyocytes. You will develop phase-appropriate analytical methods for drug substance, product, and intermediates, supporting IND-enabling and early clinical programs.
The role is lab-based, partnering with Biology, Developmental Sciences, CDMOs, and contract testing labs to establish analytical excellence within Chemistry
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