Principal Research Scientist I, Biologics Analytical Research & Development

Initial Therapeutics, Inc.; North Chicago (IL); On-site; USD 90,000 - 130,000; Full time

Job summary

A leading biopharmaceutical company seeks a skilled scientist to join their Biologics Analytical R&D team. The role involves developing advanced analytical techniques for therapeutic proteins, mentoring colleagues, and contributing to innovative product development strategies. Ideal candidates will have a PhD and expertise in mass spectrometry and protein characterization. This on-site position offers a dynamic work environment and opportunities for professional growth.

Benefits

Paid time off

Medical/Dental/Vision insurance

401(k) plan

Short-term incentive programs

Long-term incentive programs

Qualifications

• PhD with 6+ years experience in Analytical Chemistry, Biochemistry, or Biology.
• Deep understanding of protein characterization by mass spectrometry.

Responsibilities

• Lead development of LC-MS based characterization methods for biologics.
• Participate in cross-functional teams to guide analytical strategy.
• Mentor and train colleagues in analytical development.

Skills

Analytical Chemistry

Biochemistry

Protein Characterization

Mass Spectrometry

HPLC

Education

PhD

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader to develop and market advanced therapies that address some of the world's most complex and serious diseases.

AbbVie Biologics Analytical Research & Development (Biologics Analytical R&D) is a global analytical sciences organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative therapeutic biologic medicines and spans from the selection of Discovery candidate molecules through the transition of analytical methods and testing to commercial labs to support product launch. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Biologics Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies.

The biologics characterization group develops state-of-the-art analytical techniques for in-depth characterization of therapeutic proteins and other novel biologic molecules using mass spectrometry and other advanced analytical techniques. We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates. The ideal candidate will have CMC expertise in analytical development for biologics. The candidate will be responsible for assisting with the development and execution of analytical methods to support CMC and will participate in phase-appropriate characterization of material and products at all stages of development process, as well as monitoring completion of tasks and projects.

Key Responsibilities

• Leads development and implementation of LC-MS based extended characterization methods to support complex biologic programs at various phases. Previous analytical experience with ADCs is preferred.
• Actively participates in cross-functional teams within Biologics Analytical Research and Development to guide analytical strategy and provide support to process and formulation scientists. Openly share scientific expertise and collaboratively help the team to generate innovative solutions to problems.
• Advances scientific expertise within function. Proactively advises and shares knowledge and expert opinions with subordinates, peers, and senior management. Mentors and trains colleagues and assesses current and emerging business challenges enabling functional goal achievement.
• Ensure quality and effectiveness of key results of major project plans through sound design, early risk assessments, and implementation of fallback strategies.
• Sources and identified emerging scientific trends in the field of molecular characterization of biotherapeutics from internal and external sources and assess relevance. Integrates trends into functional short-term objectives. Advances technology and direction within area of discipline.
• Applies imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas.
• Make significant contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.
• Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies.

Qualifications

• PhD (with 6+ years experience) in scientific discipline (e.g., Analytical Chemistry, Biochemistry, or Biology) with previous laboratory experience.
• Deep understanding of protein characterization by mass spectrometry (e.g., peptide mapping, intact mass analysis) and other biophysical techniques (e.g., spectroscopy, structure, and binding).
• Practical experience and strong knowledge of protein HPLC (e.g., SEC, IEX, HIC), capillary electrophoresis/isoelectric focusing, and other separation techniques as applied to protein analysis.
• Must possess a solid understanding of protein chemistry and biochemistry, particularly as related to biologics drug development process and formulation. Experiences with the development of antibody drug conjugates (ADCs), and other complex biologic modalities are plus.
• Proven ability to innovate with a history of new or improved product release.
• Interacts well with diverse groups and maintains strong working relationship with internal and external collaborators.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• This is an on-site opportunity located in AbbVie's campus in north IL.
• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html