Principal Research Scientist I

AbbVie Inc; Worcester (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

AbbVie is seeking an Immunosafety Lead to drive in silico and in vitro assessments while mentoring junior scientists. The role entails integrate scientific leadership across multiple therapeutic projects within a collaborative team environment. Ideal candidates should possess deep experience in immunogenicity with a strong focus on results and effective communication.

Benefits

Paid time off (vacation, holidays, sick)

Medical/dental/vision insurance

401(k) eligibility

Short-term and long-term incentive programs

Qualifications

• 6+ years experience with Ph.D. or 12+ years with Master's; expertise in immunogenicity.
• Extensive experience with multicolor flow cytometry.
• Strong project management and collaboration skills.

Responsibilities

• Lead application of in silico and in vitro immunogenicity platforms.
• Supervise junior scientists in assessments.
• Author publications and regulatory documents.

Skills

Immunogenicity predictions

Cell-based functional assays

Interpersonal communication

Education

Ph.D. in Biological Sciences, Cellular Immunology, or related field

Master's Degree in Biological Sciences, Cellular Immunology, or related field

Bachelor's Degree in Biological Sciences, Cellular Immunology, or related field

Tools

FlowJo software

BD LSRFortessa

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

The candidate will apply their immunosafety and immunogenicity expertise to provide scientific and technical leadership in a cross-functional team assessing and implementing an immunogenicity platform with in silico and in vitro strategies, while playing a crucial role as an immunosafety lead advising teams in the development of preclinical molecules for multiple projects. The candidate is also expected to mentor junior immunosafety team members, foster productive collaborations, and demonstrate effective communication within scientific teams.

Responsibilities:

• Lead integration and application of in silico and in vitro immunogenicity platforms to AbbVie’s pipeline.
• Supervise junior scientists providing scientific and technical leadership in the design and execution of in vitro immunogenicity and immunosafety assessments to support the de-risking of novel therapeutic candidates.
• Encourage ideas, drive continuous improvements, and support initiatives to enhance immunogenicity and immunosafety risk assessments of novel therapeutics.
• Represent the In Vitro Immunosafety team in cross-functional project team meetings championing the design and coordination of in vitro immunogenicity and immunosafety studies.
• Author publication, presentations, and/or regulatory documents.

Qualifications

• Ph.D. in Biological Sciences, Cellular Immunology, or related field with 6+ years of related experience OR Master Degree in Biological Sciences, Cellular Immunology, or related field with 12+ years of related experience, OR Bachelor Degree inBiological Sciences, Cellular Immunology, or related field with 14+ years of related experience.
• Extensive experience with in silico immunogenicity prediction evaluations and in vitro immunogenicity assay development and implementation.
• Deep understanding of innate and adaptive cellular immunology with strong hands-on experience in cell-based functional assays and immune cell phenotyping.
• Extensive experience with multicolor flow cytometry panel design, BD LSRFortessa instrument operation, BD FACSDive and FlowJo software, and flow cytometry data analysis.
• Proven track record of cross-functional collaborations and project management yielding productive outcomes.
• Excellent interpersonal and oral/written communication skills.
• Results-oriented work ethic and a positive "can-do" attitude with a strong sense of urgency and self-motivated desire to achieve common business goals.
• Demonstrated ability to collaborate effectively in a dynamic, cross-functional matrix environment.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html