Principal Process Chemist – Scale-Up & Innovation (Onsite)

Calico Life Sciences; South San Francisco (CA); On-site; USD 197,000 - 230,000; Full time

Job summary

Calico Life Sciences in South San Francisco, CA seeks an experienced Process Chemist to join our laboratory-based chemical development team. You will design, optimize, and scale synthetic processes for small-molecule intermediates and APIs.

The ideal candidate has a PhD in Organic Chemistry with at least 8 years in industry, strong analytical skills, and a track record of safe, scalable manufacturing; onsite five days a week.

Qualifications

• PhD in Organic Chemistry or related field with 8+ years industry experience.
• Proven ability to develop scalable synthetic processes.
• Experience with analytical techniques (HPLC/GC/LC-MS).
• Strong communication and data interpretation skills.

Responsibilities

• Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
• Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
• Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
• Perform impurity identification and synthesis
• Identify and mitigate process risks related to safety, scalability, and robustness
• Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
• Prepare clear, data-driven reports and present experimental results to project teams
• Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
• Maintain accurate lab documentation and adhere to all safety and compliance standards

Skills

Process chemistry expertise

Problem solving

Independent worker

Team collaboration

Communication skills

cGMP knowledge

Education

PhD in Organic Chemistry

Tools

HPLC

GC

LC-MS

Analytical instruments

Job description

Calico Life Sciences in South San Francisco, CA seeks an experienced Process Chemist to join our laboratory-based chemical development team. You will design, optimize, and scale synthetic processes for small-molecule intermediates and APIs.

The ideal candidate has a PhD in Organic Chemistry with at least 8 years in industry, strong analytical skills, and a track record of safe, scalable manufacturing; onsite five days a week.