Principal Oligonucleotide Scientist

Eurofins QTA Inc.; Lancaster (Lancaster County); On-site; USD 70,000 - 90,000; Full time

Job summary

A leading life sciences company is seeking a Mass Spectrometry Subject Matter Expert to support analytical development for biopharmaceutical products. The role involves method development, troubleshooting, and mentoring junior staff. Excellent benefits and a full-time schedule are offered.

Benefits

Comprehensive Medical Coverage

Dental Options

Vision Options

Qualifications

• 4+ years of relevant experience in the bio/pharmaceutical industry.
• Hands-on experience with multiple types of mass spectrometers.
• Extensive knowledge of oligonucleotide based drug products.

Responsibilities

• Perform method development and validation of biopharmaceutical products.
• Guide junior scientists and troubleshoot method problems.
• Develop and validate new QC methods for oligonucleotides.

Skills

Communication

Organizational Skills

Time Management

Self-Motivation

Adaptability

Education

B.S. / M.S. degree in Chemistry

Biology

Biochemistry

Tools

HPLC

Mass Spectrometry

GC/MS

LC/MS

HRMS

Job description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.

In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

Job Description

• Function as an MS subject matter expert within Analytical Development and be viewed as peer to other MS SMEs within Eurofins network
• Perform method development, feasibility, qualification and/or validation of methods in support of biopharmaceutical products using primarily Mass spectrometry
• Execute identification of unknown compounds with minimal support
• Develop and execute validation plans
• Troubleshoot method and instrumentation problems
• Generate complete, accurate, and concise documentation using electronic systems and laboratory notebook
• Author documents (e.g., development reports, methods and client reports)
• Give presentations for training and client reviews
• Have a strong understanding of current regulatory expectation
• Effectively guide more junior scientists on technical issues
• Use office and instrumentation specific computer software
• Contribute to set up an oligonucleotide testing laboratory and establish processes, workflows and general operations
• Developing and validating new QC methods to assess the suitability, stability, and functionality of a range of oligonucleotides through a variety of analytical and functional tests
• HPLC and high resolution mass spectrometry method development for oligonucleotide characterization
• Installation and verification of equipment, documenting processes, and training operators
• Support various analytical instrument operation, maintenance and troubleshooting to sustain analytical performance, data reproducibility and reliability to deliver results to project teams within a timely manner
• Champion and implement new and innovative analytical applications and technology
• Advise clients on analytical scope to meet technical and regulatory requirements
• Handling any customer related queries where necessary and liaising with the team to problem solve these queries if needed
• Provide training/mentoring to junior staff

Qualifications

• B.S. / M.S. degree in Chemistry, Biology, biochemistry or related technical discipline with 4+ years of relevant experience, either post-doctoral or in the bio/pharmaceutical industry
• Hands-on experience in use of multiple types of mass spectrometers (GC/MS, LC/MS, HRMS)
• Experience with identification of unknown materials
• Ability to work independently and as part of a team with internal and external clients, self‑motivation, adaptability, and a positive attitude.
• Strong organizational and time management skills
• Excellent communication (oral and written) and attention to detail
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies
• Authorization to work in the United States indefinitely without restriction or sponsorship.
• Extensive knowledge of oligonucleotide based drug products including ASO, siRNA, mRNA
• Subject matter expert analytical chemistry knowledge including theory and application of three or more chromatographic and spectroscopic techniques for identification, purity, and assay of various analytes
• Operate and troubleshoot available instruments including HPLC and MS
• Experience with an assortment of different HPLC separations which includes IEX, RP, SEC, etc.
• Hands-on experience in QC of oligonucleotides

Additional Information

Position is full-time position, Monday - Friday 8:00am - 4:00pm. Candidates currently living within a commutable distance of Lancaster, PA are encouraged to apply.

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options

Eurofins USA BioPharma Services is a Disabled and Veteran Equal Employment Opportunity employer.