Principal Investigator (MD/DO)

Alliance Clinical; Oklahoma City (OK); On-site; USD 180,000 - 250,000; Full time

Job summary

Alliance Clinical Network in Oklahoma City is seeking an Internal Medicine / Family Medicine or Specialist physician with clinical research experience to help build a brand-new clinical research site from the ground up as Principal Investigator.

You will provide medical oversight, guide trial design, ensure participant safety, and collaborate with sponsors, CROs and site staff. This role offers a path to leadership within a growing network while maintaining meaningful clinical engagement.

Qualifications

• MD or DO with Internal Medicine, Family Medicine or Specialist background.
• Active, unrestricted Oklahoma medical license.
• Prior clinical research experience as PI or Sub-Investigator required.
• Strong clinical judgment and participant safety focus.
• Familiarity with ICH-GCP and FDA clinical research regulations.
• Board certification.
• DEA registration, if required by study protocols.

Responsibilities

• Provide medical oversight for assigned clinical trials.
• Protect safety, rights, and well-being of participants.
• Review eligibility and oversee screening outcomes.
• Review adverse events and safety trends.
• Oversee medical assessments and histories.
• Guide Sub-Investigators and site staff.
• Collaborate with sponsors, CROs, IRBs, and Alliance leadership.
• Participate in site initiation, monitoring, and close-out activities.
• Maintain compliance with protocols and FDA regulations.

Skills

Clinical research

PI leadership

Regulatory knowledge

Data review

Education

MD/DO

Oklahoma medical license

Tools

ICH-GCP

FDA regulations

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

FullTime Professional Oklahoma City, Oklahoma City, OK, US

2 days ago Requisition ID: 1361

Help Build a New Clinical Research Site From the Ground Up

About Alliance Clinical Network

At Alliance Clinical Network, we’re advancing medical innovation through high-quality, patient-centered clinical research. Our growing network is built around a simple belief: great research starts with great people, strong clinical leadership, and a commitment to doing what’s right for patients.

We’re looking for an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience who wants to play a meaningful role in bringing that mission to life in Oklahoma City.

The Opportunity

This is more than an opportunity to serve as a Principal Investigator. It’s an opportunity to help build a new clinical research site from the ground up.

As the Principal Investigator, you’ll provide clinical and medical guidance as the site establishes itself in the community and grows its research portfolio. Your experience, clinical judgment, and perspective will help shape the site’s success while giving you the opportunity to make an impact without the demands of a traditional full-time clinical practice.

This is an especially attractive opportunity for a physician who enjoys medicine & clinical research and wants to remain clinically engaged, but is looking for a more predictable schedule; as well as the opportunity to fully contribute their time to clinical research.

Why This Opportunity Is Different

Build, don’t inherit.
Help establish a brand-new research site and play a visible role in shaping its clinical and research presence in the community.

Have a meaningful voice.
Your medical expertise and clinical judgment will directly contribute to delivering a high-quality experience for participants.

Stay engaged in cutting edge medicine.
Maintain meaningful clinical involvement without the high volume / low impact environment of a traditional practice.

Bring research opportunities to local patients.
Help connect patients with clinical trials investigating new therapies and advancing the future of medicine.

Work with a team behind you.
You won’t be expected to build and manage the research operation yourself. Experienced clinical operations, regulatory, quality, and research staff provide the infrastructure and day‑to‑day support needed to conduct successful trials.

Grow with Alliance.
As the site develops, this role provides an opportunity to establish yourself as a key physician leader within a growing clinical research network.

What You’ll Do

As Principal Investigator, you will provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.

• Serve as the study physician and provide medical oversight for assigned clinical trials.
• Protect the safety, rights, and well-being of research participants throughout the study.
• Review and confirm participant eligibility and provide medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
• Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
• Serve as a clinical resource for study-related medical questions and safety concerns.
• Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
• Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
• Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
• Support timely safety reporting, medical documentation, and resolution of clinical data queries.
• Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
• Contribute to a culture of quality, continuous improvement, and patient-centered research.

A Schedule Designed Around Your Life

• Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
• No overnight call & rare urgent escalations
• Predictable research visits and structured protocols
• Focused interactions with study participants rather than a traditional high-volume clinic
• A dedicated research team managing day-to-day study coordination

Training & Support

• Structured PI onboarding and mentorship
• Protocol-specific training
• Support from other experienced Principal Investigators
• Ongoing partnership with clinical operations, regulatory, and quality teams
• Established SOPs, templates, and documentation workflows
• Continued support throughout the life of your studies

What We’re Looking For

Requirements

• MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
• Active, unrestricted Oklahoma medical license
• Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
• Strong clinical judgment and commitment to participant safety
• Interest in clinical research and advancing medical innovation
• Comfort reviewing structured clinical data and study-specific medical information
• Strong communication, documentation, and confidentiality practices
• Familiarity with ICH-GCP and FDA clinical research regulations
• Board certification
• DEA registration, if required by applicable study protocols

Build Something That Matters

If you’re an Internal Medicine / Specialist physician looking for a way to stay engaged in medicine, contribute to the advancement of new therapies, and have a meaningful role in building something new - we’d love to talk with you.

This is an opportunity to bring your medical & clinical research expertise to a greater patient population & new clinical research site.

Help us build the future of clinical research inOklahoma City!