Principal Investigator (MD/DO)

Alliance Clinical; Cleveland (OH); On-site; USD 150,000 - 240,000; Full time

Job summary

Alliance Clinical Network in Cleveland, OH seeks an MD/DO with clinical research experience for a Principal Investigator role to help build a new clinical research site from the ground up. You will provide medical oversight, guide study design, ensure patient safety, and manage data quality while staying clinically engaged with a predictable schedule.

The role emphasizes building local research opportunities, collaborating with sponsors and staff, and helping establish a strong community

Qualifications

• MD or DO with a background in Internal Medicine, Family Medicine or a Specialist.
• Active, unrestricted Ohio medical license.
• Prior clinical research experience in a PI/Sub-Investigator role is required
• Strong clinical judgment and commitment to participant safety
• Familiarity with ICH-GCP and FDA clinical research regulations

Responsibilities

• Provide medical oversight and leadership for assigned clinical trials.
• Protect the safety, rights, and well-being of participants throughout the study.
• Review participant eligibility and medical outcomes.
• Review adverse events and safety trends.
• Provide guidance to Sub-Investigators and study staff.
• Collaborate with sponsors, CROs, IRBs, and leadership.
• Participate in site initiation, monitoring, and close-out visits.
• Review laboratory results, ECGs, vitals, and other assessments.

Skills

Strong clinical judgment

Participant safety focus

Excellent communication

Documentation accuracy

Education

MD/DO degree

Active Ohio medical license

Board certification

Tools

ICH-GCP familiarity

FDA clinical research regulations

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

FullTime Professional Cleveland, Cleveland, OH, US

3 days ago Requisition ID: 1356

Help Build a New Clinical Research Site From the Ground Up

About Alliance Clinical Network

At Alliance Clinical Network, we're advancing medical innovation through high-quality, patient-centered clinical research. Our growing network is built around a simple belief: great research starts with great people, strong clinical leadership, and a commitment to doing what's right for patients.

We're looking for an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience who wants to play a meaningful role in bringing that mission to life in Cleveland, OH.

The Opportunity

This is more than an opportunity to serve as a Principal Investigator. It's an opportunity to help build a new clinical research site from the ground up.

As the Principal Investigator, you'll provide clinical and medical guidance as the site establishes itself in the community and grows its research portfolio. Your experience, clinical judgment, and perspective will help shape the site's success while giving you the opportunity to make an impact without the demands of a traditional full-time clinical practice.

This is an especially attractive opportunity for a physician who enjoys medicine & clinical research and wants to remain clinically engaged, but is looking for a more predictable schedule; as well as the opportunity to fully contribute their time to clinical research.

Why This Opportunity Is Different

• Build, don't inherit.
• Have a meaningful voice.
• Stay engaged in cutting edge medicine.
• Bring research opportunities to local patients.
• Work with a team behind you.
• Grow with Alliance.

What You'll Do

As Principal Investigator, you will provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.

• Serve as the study physician and provide medical oversight for assigned clinical trials.
• Protect the safety, rights, and well-being of research participants throughout the study.
• Review and confirm participant eligibility and provide medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
• Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
• Serve as a clinical resource for study-related medical questions and safety concerns.
• Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
• Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
• Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
• Support timely safety reporting, medical documentation, and resolution of clinical data queries.
• Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
• Contribute to a culture of quality, continuous improvement, and patient-centered research.

A Schedule Designed Around Your Life

• Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
• No overnight call & rare urgent escalations
• Predictable research visits and structured protocols
• Focused interactions with study participants rather than a traditional high-volume clinic
• A dedicated research team managing day-to-day study coordination

Training & Support

• Structured PI onboarding and mentorship
• Protocol-specific training
• Support from other experienced Principal Investigators
• Ongoing partnership with clinical operations, regulatory, and quality teams
• Established SOPs, templates, and documentation workflows
• Continued support throughout the life of your studies

What We're Looking For

Requirements

• MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
• Active, unrestricted Ohio medical license
• Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
• Strong clinical judgment and commitment to participant safety
• Interest in clinical research and advancing medical innovation
• Comfort reviewing structured clinical data and study-specific medical information
• Strong communication, documentation, and confidentiality practices
• Familiarity with ICH-GCP and FDA clinical research regulations
• Board certification
• DEA registration, if required by applicable study protocols

Build Something That Matters

If you're an Internal Medicine / Specialist physician looking for a way to stay engaged in medicine, contribute to the advancement of new therapies, and have a meaningful role in building something new - we'd love to talk with you.

This is an opportunity to bring your medical & clinical research expertise to a greater patient population & new clinical research site.

Help us build the future of clinical research inCleveland!