Principal Investigator (MD/DO)

System One; Columbus (OH); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Health and welfare benefits (medical,d

Dental benefits

Vision benefits

Spending accounts

Life insurance

401(k) plan

Voluntary plans

Job summary

System One is seeking a Principal Investigator (MD/DO) in Columbus, OH to provide medical leadership and oversee clinical trials onsite. You will review eligibility, monitor safety data, perform medical assessments, and guide site staff across multiple studies.

The role requires an active Ohio medical license, board certification, and prior PI or sub-investigator experience. DEA registration may be required by protocol. Competitive benefits are offered.

Qualifications

• MD or DO with licensure to practice in Ohio.
• Board-certified and eligible for clinical trial leadership.
• DEA registration if required by study protocols.
• Active, unrestricted Ohio medical license.
• Prior PI or sub-investigator experience in clinical trials.

Responsibilities

• Provide medical oversight and clinical leadership for trials.
• Act as study physician, review eligibility and screening outcomes.
• Review AEs/SAEs and participant safety trends.
• Perform or oversee medical assessments and endpoints.
• Guide subs and site staff on clinical matters and safety.
• Be the medical resource for sponsors, CROs, and leadership.
• Participate in site visits, monitoring, and close-out activities.
• Review laboratory data, ECGs, vital signs, and other metrics.

Skills

Clinical leadership

Patient safety oversight

Study coordination

Education

MD/DO

Board certification

Job description

Job Title: Principal Investigator (MD/DO)
Location: Columbus, OH
Work Model: Onsite – onsite

Responsibilities

• Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
• Serve as the study physician, reviewing participant eligibility and providing medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
• Offer clinical guidance and oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and site staff.
• Act as a resource for study-related medical questions and safety concerns.
• Collaborate with study sponsors, CROs, IRBs, and company leadership throughout each trial.
• Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings.
• Review clinical data such as laboratory results, ECGs, vital signs, and other assessments.

Requirements

• MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
• Active, unrestricted Ohio medical license.
• Prior clinical research experience as a Principal Investigator, Sub-Investigator, or other clinical research physician role.
• Board certification.
• DEA registration, if required by study protocols.

System One, and its subsidiaries including Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Ref: #568-Clinical

Ref: #568-Clinical