Clinical Trials Principal Investigator (MD/DO) - Onsite

System One; Cleveland (OH); On-site; USD 125,000 - 170,000; Full time

Benefits offered by this job

Health and welfare benefits (medical,‑

Dental, vision coverage

Participation in 401(k) plan

Job summary

System One is seeking a US board certified MD/DO to work as a Principal Investigator overseeing clinical trials in Cleveland, OH. The role involves providing medical oversight, ensuring participant safety, and collaborating with study teams and sponsors.

This full-time, onsite position requires an active Ohio medical license and prior clinical research experience as a Principal Investigator or Sub-Investigator.

Qualifications

• MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
• Active, unrestricted Ohio medical license.
• Prior clinical research experience as a Principal Investigator, Sub-Investigator, or other clinical research physician.
• Strong clinical judgment and commitment to participant safety.
• Interest in clinical research and advancing medical innovation.
• Board certification.
• DEA registration, if required by study protocols.

Responsibilities

• Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
• Serve as the study physician, reviewing participant eligibility and providing medical oversight for screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
• Offer clinical guidance and oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and site staff.
• Collaborate with study sponsors, CROs, IRBs, and company leadership throughout each trial.
• Participate in site initiation visits, monitoring visits, close-out activities, and other study meetings.
• Review clinical data such as laboratory results, ECGs, vital signs, and other assessments.

Skills

Clinical oversight

Participant safety

Medical judgment

Education

MD/DO degree

Ohio medical license

Job description

System One is seeking a US board certified MD/DO to work as a Principal Investigator overseeing clinical trials in Cleveland, OH. The role involves providing medical oversight, ensuring participant safety, and collaborating with study teams and sponsors.

This full-time, onsite position requires an active Ohio medical license and prior clinical research experience as a Principal Investigator or Sub-Investigator.