Principal Formulations Scientist

Eurofins US Network; San Diego (CA); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

Comprehensive medical coverage

Dental and vision options

Life and disability insurance

401(k) with company match

Paid holidays and vacation

Job summary

Eurofins US Network in San Diego, CA seeks a Principal Formulations Scientist to develop and characterize complex formulations for various delivery routes, while applying AI and PBPK/PBBM modeling to predict performance. You will work independently as a technical resource, manage data and documentation, and collaborate with CROs and partner labs.

The role emphasizes hands-on lab work, data-driven decision making, and writing study protocols and reports, with ELN standards development as part of

Qualifications

• Experience with complex formulations and with formulating and studying poorly behaved compounds.
• Experience performing compound risk assessments.
• Strong analytical skills, both conceptual and hands-on in the lab.
• Experience with prompting and the application of AI.
• Excellent communication, organization and attention to detail.
• Experience with GastroPlus or other PBPK/PBBM software.
• Experience with statistical analysis.
• ELN experience, including developing ELN standards.

Responsibilities

• Design and develop prototype and complex formulations (solutions, suspensions and enabling formulations) for oral, subcutaneous, and/or intravenous (sterile) delivery to support in-vitro and in-vivo studies.
• Formulate and characterize poorly behaved compounds, including those with low solubility or poor stability, and develop strategies to overcome their limitations.
• Contribute to compound risk assessments utilizing physicochemical property information, in vivo performance data, and predictive tools.
• Design and interpret studies of solubility, chemical and physical stability, and in-vitro performance (non-sink dissolution, precipitation).
• Apply analytical techniques (HPLC, DSC, PXRD, spectroscopy), both conceptually and in the lab, to characterize compounds and formulations.
• Use physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM) tools such as GastroPlus to predict compound and formulation performance.
• Partner in the novel application of AI in the advancement of new molecules.
• Curate data from contract research organizations (CROs) and other external partners.
• Write and review study protocols and technical reports.
• Record work in an ELN, and help develop ELN standards and best practices.

Skills

Complex formulations

Compound risk assessments

Analytical skills

AI prompting

Communication & organization

PBPK/PBBM software

Statistical analysis

ELN experience

Education

PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering or related field

Tools

GastroPlus

Job description

San Diego, CA, USA

Full-time

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.pe over the past 20 years.

Job Description

Eurofins PSS West is looking for a Principal Formulations Scientist to develop and characterize formulations on complex and poorly behaved drug candidates, advance data management and documentation practices, and partner in the innovative application of AI at a client site in San Diego, CA. This scientist combines hands-on lab skills with data-driven, modeling-based assessment of compounds. They are expected to work independently and act as a technical resource for the team.

Responsibilities include, but are not limited to:

• Design and develop prototype and complex formulations (solutions, suspensions and enabling formulations) for oral, subcutaneous, and/or intravenous (sterile) delivery to support in-vitro and in-vivo studies.

• Formulate and characterize poorly behaved compounds, including those with low solubility or poor stability, and develop strategies to overcome their limitations.

• Contribute to compound risk assessments utilizing physicochemical property information, in vivo performance data, and predictive tools.

• Design and interpret studies of solubility, chemical and physical stability, and in-vitro performance (non-sink dissolution, precipitation).

• Apply analytical techniques (HPLC, DSC, PXRD, spectroscopy), both conceptually and in the lab, to characterize compounds and formulations.

• Use physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM) tools such as GastroPlus to predict compound and formulation performance.

• Partner in the novel application of AI in the advancement of new molecules.

• Curate data from contract research organizations (CROs) and other external partners.

• Write and review study protocols and technical reports.

• Record work in an ELN, and help develop ELN standards and best practices.

Qualifications

The Ideal Candidate would possess:

• Experience with complex formulations and with formulating and studying poorly behaved compounds

• Experience performing compound risk assessments

• Strong analytical skills, both conceptual and hands-on in the lab

• Experience with prompting and the application of AI

• Excellent communication, organization and attention to detail

• Experience with GastroPlus or other PBPK/PBBM software

• Experience with statistical analysis

• ELN experience, including developing ELN standards

Basic Minimum Qualifications:

• PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering or a related field, with 0–2+ years of related experience

• Authorization to work in the United States indefinitely without restriction or sponsorship

• Candidates within commuting distance of San Diego, CA are encouraged to apply

Additional Information

• Comprehensive medical coverage, with dental and vision options

• Life and disability insurance

• 401(k) with company match

• Paid holidays and vacation

• Compensation Range: $90,000-$115,000/yr

Eurofins Lancaster Laboratories Professional Scientific Services® (PSS) is a global, award-winning insourcing solution that places our people at our clients’ site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client’s quality systems and equipment.

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.