Principal Clinical Scientist

Alignerr Corp.; Charlotte (AR); Remote; USD 110,000 - 193,000; Part time

Job summary

Alignerr Corp. seeks a Principal Clinical Scientist to shape how real-world clinical data informs AI training for regulatory submissions. You’ll design and review trial prototypes, audit results, and ensure methodological rigor across datasets.

This remote, hourly-contract role offers flexible scheduling (10–40 hours/week) and collaboration with leading AI research teams. You’ll provide structured feedback to strengthen AI reasoning about endpoints and outcomes.

Qualifications

• Senior-level experience designing clinical trial protocols for regulatory submission.
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent international bodies.
• Strong grounding in biostatistics, translational science, or related methodology.
• Naturally detail-oriented with a systematic, evidence-driven approach to evaluation.
• Clear and precise written communicator able to articulate complex scientific reasoning in feedback.

Responsibilities

• Design and review clinical trial protocols used to generate regulator-ready datasets for AI training.
• Interpret and audit clinical trial results to ensure accuracy and regulatory alignment.
• Evaluate AI-generated clinical analyses for scientific soundness and methodological rigor.
• Provide expert, structured feedback to improve AI models' reasoning about endpoints and outcomes.
• Work independently and asynchronously — fully on your own schedule.

Skills

Senior-level protocol design

Regulatory data interpretation

Biostatistics knowledge

Regulatory submissions familiarity

Structured feedback writing

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your deep expertise in clinical trial design and regulatory science could directly influence how AI understands and evaluates real-world medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research — helping ensure that the clinical intelligence built into next-generation AI systems meets the standards expected in real regulatory submissions.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory expectations
• Evaluate AI-generated clinical analyses for scientific soundness and methodological rigor
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Work independently and asynchronously — fully on your own schedule

Who You Are

• Senior-level experience designing clinical trial protocols intended for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent international bodies
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Naturally detail-oriented with a systematic, evidence-driven approach to evaluation
• Clear and precise written communicator — able to articulate complex scientific reasoning in structured feedback

Nice to Have

• Prior experience with data annotation, data quality assurance, or evaluation systems
• Familiarity with AI tools or clinical informatics platforms
• Background in pharmacology, oncology, rare disease, or another specialist therapeutic area
• Experience contributing to regulatory dossiers, CTD submissions, or scientific advisory processes

Why Join Us

• Work directly on frontier AI systems impacting clinical and biomedical research at a global scale
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, task-based expert work
• Influence how AI understands, evaluates, and reasons about real-world clinical evidence
• Collaborate with world-leading AI research teams and labs
• Potential for ongoing work and contract extension as new projects launch