Prime & Base Editing Scientist in Reproductive Genomics

preventive-medicine; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Preventive Medicine in South San Francisco is seeking a hands-on experimentalist to build and optimize next-generation gene editing systems for reproductive genetics, focusing on prime and base editing in cell-based and embryo-relevant models.

You will work across molecular biology, genomics, embryology, and in vivo teams, translating cell-based results into oocyte, zygote, and embryo experiments, with ownership of difficult experiments and rapid learning.

Qualifications

• BS or higher in a relevant field (we care more about your experience than your formal education)
• 2+ years of industry experience in biotechnology.
• Demonstrated gene editing experience with next‑generation platforms (prime and/or base editing).
• Strong molecular biology skills.
• Proficiency in mammalian tissue culture, including sterile technique and basic cell‑based assays.
• Clear evidence of strong work ethic, high aptitude, and ownership in previous roles or projects.

Responsibilities

• Optimize prime and base editing in mammalian cells and embryo-relevant models, including protein and guide engineering.
• Execute molecular biology workflows, including cloning, PCR/qPCR, amplicon prep, and sequencing-based analysis.
• Measure editing efficiency, byproducts, mosaicism, specificity, and off-target activity.
• Support NGS and single-cell workflows to characterize editing outcomes and embryo-relevant biology.
• Translate cell-based editing results into oocyte, zygote, and embryo experiments.
• Work across molecular biology, genomics, embryology, and in vivo teams to solve technical problems.

Skills

Gene editing (prime/base)

Molecular biology

Mammalian cell culture

Strong work ethic

Education

BS or higher in a relevant field

Tools

Cloning

PCR/qPCR

NGS

Single-cell workflows

Job description

Preventive Medicine in South San Francisco is seeking a hands-on experimentalist to build and optimize next-generation gene editing systems for reproductive genetics, focusing on prime and base editing in cell-based and embryo-relevant models.

You will work across molecular biology, genomics, embryology, and in vivo teams, translating cell-based results into oocyte, zygote, and embryo experiments, with ownership of difficult experiments and rapid learning.