Preformulation Scientist — Solubility & Formulation (Equity)

Scorpion Therapeutics; United States; On-site; USD 135,000 - 158,000; Full time

Benefits offered by this job

Equity

Health/Dental/Vision/Life/Disability

401k match

Learning stipend

Wellness stipend

Paid time off

Job summary

Scorpion Therapeutics is seeking a senior preformulation scientist to lead design and evaluation of formulations for drug discovery and early development. You will communicate strategy and risks to cross-functional teams and oversee analytical method development.

Ideal candidates hold an MS or PhD in Pharmaceutical Sciences with hands-on experience in solubility, solid-state analysis, and HPLC/UPLC, including dose verification and SGF FaSSIF/FeSSIF methods.

Qualifications

• MS/PhD in Pharmaceutical Sciences or related field with industry experience.
• Hands-on formulation of poorly water-soluble compounds in discovery settings.
• Experience developing analytical methods (HPLC/UPLC) and dosage verification.

Responsibilities

• Serve as preformulation representative on drug discovery and early development teams.
• Design and evaluate formulations for non-clinical studies to achieve exposure and stability.
• Lead preformulation assessments of NCEs, including solubility and solid-state properties.
• Conduct salt, co-crystal, and solid-form screening for optimization.
• Apply solubility-enabling technologies for poorly soluble compounds.
• Develop/qualify analytical methods and oversee CRO work.
• Contribute data to candidate selection and regulatory documentation.

Skills

Physicochemical properties

Solubility-enabling formulations

Analytical method development

Project management

Clear communication

Education

MS in Pharmaceutical Sciences

PhD in Pharmaceutical Sciences

Tools

HPLC/UPLC

Mass spectrometry

Job description

Scorpion Therapeutics is seeking a senior preformulation scientist to lead design and evaluation of formulations for drug discovery and early development. You will communicate strategy and risks to cross-functional teams and oversee analytical method development.

Ideal candidates hold an MS or PhD in Pharmaceutical Sciences with hands-on experience in solubility, solid-state analysis, and HPLC/UPLC, including dose verification and SGF FaSSIF/FeSSIF methods.