Scientist - Preformulation

BioTalent; South San Francisco (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

BioTalent is seeking a Scientist or Scientist II to lead preformulation activities across novel small molecule discovery programs. This is a highly hands-on role, with approximately seventy percent laboratory work and the opportunity to influence programs from early discovery through IND submission.

Ideal candidates have a PhD with 3-4 years, MS with 6-8 years, or BS with 10+ years of relevant industry experience, and strong preformulation experience within small molecule drug discovery.

Qualifications

• PhD/MS/BS with relevant industry experience and preformulation expertise.
• Experience with DSC, melting point, solubility and SGF.
• Experience progressing programs from discovery through IND.

Responsibilities

• Lead preformulation studies supporting candidate selection and progression.
• Perform hands-on laboratory work including DSC, melting point, solubility and SGF.
• Develop and utilize HPLC-based analytical methods.
• Partner closely with Discovery, Pharmacology, DMPK and CMC teams.
• Support external CROs while retaining internal scientific ownership.

Skills

Preformulation

Small molecule drug discovery

Bench-work

Education

PhD

MS

BS

Tools

DSC

HPLC

Solubility testing

SGF

Job description

BioTalent is supporting an innovative biotech seeking a Scientist or Scientist II to lead preformulation activities across novel small molecule discovery programs.

This is a highly hands-on role, with approximately 70% laboratory work and the opportunity to influence programs from early discovery through IND submission.

Key Responsibilities

• Lead preformulation studies supporting candidate selection and progression
• Perform hands-on laboratory work including Differential Scanning Calorimitry (DSC), melting point, solubility and Supersaturated Gel Formation (SGF)
• Develop and utilize HPLC-based analytical methods
• Partner closely with Discovery, Pharmacology, DMPK and CMC teams
• Support external CROs while retaining internal scientific ownership

Ideal Background

• PhD + 3-4 years, MS + 6-8 years, or BS + 10+ years of relevant industry experience
• Strong preformulation experience within small molecule drug discovery
• Experience characterizing new molecular entities and assessing developability
• Exposure to programs progressing from discovery into development, ideally through IND
• Hands-on scientist who enjoys working at the bench rather than primarily managing outsourced work

Why Join?

• Become the key bridge between Discovery and CMC Development
• Directly influence candidate selection and formulation strategy
• Build expertise and potentially help establish future preformulation capabilities within the organization
• High-visibility role with significant scientific impact across the pipeline

For a confidential discussion, please contact Greg Hammond at BioTalent.