Postdoctoral Scientist - O'Brown Lab

HHMI; New Brunswick (NJ); On-site; USD 70,000 - 82,000; Full time

Job summary

HHMI’s O’Brown Lab in New Jersey seeks a Postdoctoral Scientist to study BBB development using zebrafish and mouse models. The role involves designing experiments, mentoring undergraduates, and collaborating with lab members in a fast-paced setting.

You will lead vascular biology research, perform in vivo imaging, RNA sequencing analysis, and molecular biology tasks, then present findings in internal meetings and publications. Strong independence is essential.

Qualifications

• Ph.D. in Developmental Biology, Molecular Biosciences, or a related field.
• Experience with in vivo techniques, zebrafish preferred or mouse models.
• Hands-on skills in vascular biology and BBB research.
• Experience with RNA sequencing workflows and data interpretation.
• Proficiency in cloning, PCR, and genotyping.

Responsibilities

• Lead independent research projects focused on vascular biology and BBB development.
• Conduct experiments in zebrafish and mouse models, including microinjections, live imaging, and behavioral studies.
• Apply molecular biology techniques including PCR, cloning, and genotyping.
• Perform in vivo imaging and high-resolution microscopy to visualize vascular function and BBB dynamics.
• Analyze or support RNA sequencing experiments.
• Supervise undergraduate trainees and contribute to an open, collaborative lab culture.
• Document and present findings in internal meetings and scientific publications.

Skills

Zebrafish experiments

Mouse experiments

RNA sequencing workflows

Molecular cloning

PCR

Genotyping

Live imaging

Vascular biology

Data interpretation

Education

Ph.D. in Developmental Biology or Molecular Biosciences

Tools

PCR

Cloning

Genotyping

Live imaging

Job description

Primary Work Address: Rutgers University/CABM, Piscataway, NJ, 08854-5638

About the O’Brown Lab:

The O’Brown Lab at Rutgers University is unraveling the intricate mechanisms that govern the blood-brain barrier (BBB) — a specialized vascular interface that protects the brain and regulates the flow of ions, nutrients, and immune cells. The lab's work focuses on how the BBB forms and functions during development, and how its breakdown contributes to neurological diseases. Our research integrates molecular, developmental, and vascular biology to inform future therapeutic applications.

Learn more about our work

About the Role:

We are seeking a highly motivated and independent Postdoctoral Scientist to join our in-person, cross-disciplinary team. This role focuses on understanding the developmental and cellular mechanisms that regulate blood-brain barrier function using zebrafish and mouse models. Projects aim to define how vascular and surrounding neuronal and glial cells interact during development, how these interactions are disrupted in disease, and how those insights can guide translational research.

The position involves designing and executing experiments, overseeing undergraduate researchers, and collaborating closely with Dr. O’Brown and other lab members in a fast-paced, discovery-driven environment.

What You’ll Get:

• Close mentorship from Dr. O’Brown and the opportunity to mentor junior trainees.
• A focus on career development, with support for producing publications.
• Active guidance for both academic and industry career pathways — BBB research is highly applicable to both.
• Ongoing networking support, including conferences and collaboration opportunities.
• The opportunity to shape the direction of a growing, high-impact lab working at the intersection of development and neurovascular biology.

What you will do:

• Lead independent research projects focused on vascular biology and BBB development.
• Conduct experiments in zebrafish and mouse models, including microinjections, live imaging, and behavioral studies.
• Apply molecular biology techniques including PCR, cloning, and genotyping.
• Perform in vivo imaging and high-resolution microscopy to visualize vascular function and BBB dynamics.
• Analyze or support RNA sequencing experiments.
• Supervise undergraduate trainees and contribute to an open, collaborative lab culture.
• Document and present findings in internal meetings and scientific publications.

What You Bring:

• A Ph.D. in Developmental Biology, Molecular Biosciences, or a related field (e.g., Genetics, Systems Biology).
• Prior experience with in vivo techniques, ideally in zebrafish (preferred) or mouse models.
• Hands‑on skills in vascular biology, developmental imaging, and/or blood‑brain barrier research.
• Experience with RNA sequencing workflows, data interpretation, or collaboration with sequencing teams.
• Proficiency in molecular biology techniques such as cloning, PCR, and genotyping.

A strong sense of independence, with the ability to manage and lead scientific projects autonomously.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.

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Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

Hiring Pay Range

$70,000.00 - $82,250.00

Pay Type: Annual

The posted range reflects HHMI’s good faith estimate of the anticipated hiring salary range for this role at the time of posting. Actual hiring compensation is determined by a candidate’s qualifications, experience, and internal equity.

HHMI is an Equal Opportunity Employer

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