Postdoctoral Scientist

University of Pennsylvania Perelman School of Medicine; Erie, Meadville (Erie County, Crawford County); On-site; USD 50,000 - 65,000; Full time

Job summary

University of Pennsylvania (Perelman School of Medicine) seeks a highly motivated, full-time postdoctoral scientist in Ophthalmology to join a dynamic lab led by Dr. Lucie Guo. The role emphasizes molecular biology, epigenetics, gene therapy, and career development.

The candidate will conduct independent research, mentor junior researchers, prepare manuscripts and grant applications, and participate in conferences, seminars, and collaborative projects across disciplines.

Qualifications

• PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, vision science, biomedical engineering, or related field.
• Strong experimental design, data analysis, and scientific communication skills.
• Experience with CRISPR, viral vectors, and animal models is highly desirable.

Responsibilities

• Conduct independent laboratory research using molecular biology techniques and genome engineering.
• Perform mouse model experiments, tissue collection, imaging, and molecular analyses.
• Design and optimize experiments, troubleshoot issues, and maintain organized records.

Skills

Molecular cloning

Cell culture

Transfection

CRISPR-based genome editing

Flow cytometry

Biochemical assays

Education

PhD in life sciences

Tools

PCR

Viral vectors

immunofluorescence

Job description

University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral

Location: University of Pennsylvania - Perelman School of Medicine

Open Date: Aug 12, 2026

Description

The Department of Ophthalmology is seeking a highly motivated, full-time postdoctoral scientist to join a dynamic and collaborative research laboratory under the direction of the Principal Investigator (Dr. Lucie Guo, MD PhD). The successful candidate will drive to innovative research at the intersection of molecular biology, epigenetics, gene therapy, and ophthalmology while receiving mentorship in experimental design, scientific communication, grant writing, and career development.

Primary Responsibilities Include

• Conduct independent laboratory research using techniques such as molecular cloning, cell and tissue culture, transfection, CRISPR-based genome engineering, quantitative flow cytometry, and molecular and biochemical assays
• Perform animal studies, including work with mouse models, tissue collection, ocular imaging, and histologic and molecular analyses
• Design rigorous experiments, develop and optimize research protocols, and troubleshoot technical challenges independently
• Maintain accurate and organized laboratory records and ensure the quality, reproducibility, and appropriate documentation of experimental data
• Analyze and interpret research findings using appropriate quantitative and statistical methods
• Review relevant scientific literature and integrate emerging concepts and technologies into ongoing research projects
• Present research progress and findings regularly at laboratory meetings, departmental seminars, and collaborative research discussions
• Prepare figures, manuscripts, abstracts, and other scientific materials for publication in peer-reviewed journals
• Write fellowship, grant, and other funding applications
• Present research findings at local, national, and international scientific conferences
• Collaborate effectively with laboratory members, clinicians, and research partners across disciplines
• Assist with the training and mentorship of junior researchers, including research staff, graduate students, medical students, and undergraduate students
• Contribute to maintaining an organized, collegial, and productive laboratory environment
• Participate in professional-development activities and work with the Principal Investigator to establish and pursue individualized research and career goals

Qualifications

Qualified applicants should hold a PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, vision science, biomedical engineering, or a related field. Candidates should have a strong foundation in experimental design, data analysis, scientific communication, and the interpretation of research findings.

Prior experience in one or more of the following areas is highly desirable:

• Molecular biology techniques, including molecular cloning, PCR, quantitative PCR, Western blotting, and immunofluorescence
• Mammalian cell and tissue culture, transfection, and the development or use of cell-based assays
• CRISPR-based genome editing or gene regulation, including guide RNA design and validation
• Viral vector design, production, or application, particularly adeno-associated viral vectors
• Animal research, including experience with mouse models, tissue collection, genotyping, injections, imaging, or surgical procedures
• Microscopy, histology, image analysis, and quantitative data analysis

The ideal candidate will be highly motivated, organized, intellectually curious, and capable of working both independently and collaboratively. Strong written and oral communication skills, careful attention to experimental rigor and reproducibility, and a commitment to maintaining accurate research records are essential. Applicants should also demonstrate the ability to manage multiple projects, troubleshoot technical challenges, contribute constructively to a collaborative laboratory environment, and mentor junior researchers. A strong publication record and demonstrated interest in pursuing an independent scientific or academic career are preferred.