Postdoctoral Researcher - Physiology

The Medical College of Wisconsin, Inc.; United States; On-site; USD 54,000 - 70,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

403B Retirement Package

Paid vacation & holidays

Tuition reimbursement

Paid parental leave

EFAP (Employee & Family Assistance)

Job summary

The Xiao Lab at The Medical College of Wisconsin, Inc. seeks a motivated postdoctoral fellow to advance interdisciplinary research on the genetic and epigenetic basis of cardiometabolic diseases. You will integrate experimental and computational approaches using mouse models and omics to uncover disease mechanisms.

You will generate and analyze functional genomic, single-cell and spatial omics data, publish findings, and contribute to grant proposals in a highly collaborative environment.

Qualifications

• PhD in a scientific field or MD is required.
• 0 years of experience required, postdoctoral candidates welcome.
• Preferred education includes PhD or MD/PhD in physiology, cell biology, molecular biology, biochemistry, genetics, genomics, or related field.

Responsibilities

• Lead research projects on genetics, epigenetics and inter-organ crosstalk of cardiometabolic diseases.
• Conduct physiological studies using mouse models of obesity and cardiometabolic disease.
• Perform molecular and cellular experiments on mouse and human tissues, including cloning, PCR, immunoblotting, and reporter assays.
• Generate and analyze large-scale functional genomic, single-cell and spatial omics, transcriptomic and proteomic datasets.
• Prepare manuscripts, presentations, progress reports, and grant applications.
• Present findings at lab meetings and conferences.
• Mentor trainees and contribute to a collaborative research environment.

Skills

Mouse models

Mammalian cell culture

Molecular biology

Biochemistry

Cell biology

Functional genomics

Single-cell omics

Bioinformatics

Communication

Education

PhD or MD

Tools

R

Python

Job description

Summary

The Xiao Lab in the Department of Physiology at the Medical College of Wisconsin is seeking a highly motivated postdoctoral fellow to join an interdisciplinary research program investigating the genetic and epigenetic basis of cardiometabolic diseases, including obesity, metabolic liver disease, and cardiovascular disease. We integrate experimental and computational approaches to understand disease mechanisms and aim to translate our discoveries into new strategies for the prediction, prevention, and treatment of cardiometabolic disorders. The successful candidate will conduct physiological studies using mouse models and analyze mouse and patient-derived cells and tissues using comprehensive omics approaches, including functional genomics, single-cell and spatial omics, CRISPR-based screening, and proteomics. The goal of this research is to identify the genes, genetic variants, regulatory pathways, and cellular mechanisms that drive the development and progression of cardiometabolic disease.

Primary Responsibilities

• Lead research projects investigating the genetics, epigenetics, and inter-organ crosstalk associated with cardiometabolic diseases.
• Conduct physiological studies using genetically modified and diet-induced mouse models of obesity and cardiometabolic disease.
• Perform molecular and cellular experiments using mouse and human tissues/cells, including cloning, PCR, immunoblotting, and reporter assays.
• Generate, analyze, and interpret large-scale functional genomic, single-cell and spatial omics, transcriptomic, and proteomic datasets.
• Prepare manuscripts, scientific presentations, progress reports, and grant applications.
• Present research findings at laboratory meetings and scientific conferences.
• Mentor trainees, as appropriate, and contribute to a highly interactive and collaborative research environment.
• Other duties as assigned.

Knowledge – Skills – Abilities

• Experience with mouse models and/or mammalian cell culture.
• Hands-on experience with molecular biology, biochemistry, and cell biology techniques, including DNA and RNA extraction and immunoblotting.
• Experience with functional genomics and single-cell omics is preferred.
• Experience analyzing data using R and/or Python is preferred.
• Strong written and oral communication skills and the ability to work effectively in a collaborative research environment.
• A publication record demonstrating research productivity and scientific excellence.

Qualifications

• Minimum Required Education: PhD in a scientific field or MD
• Minimum Required Experience: 0 Years
• Preferred Education: PhD or MD/PhD in physiology, cell biology, molecular biology, biochemistry, genetics, genomics, or a related field.
• Preferred Experience: Mouse models and/or mammalian cell culture; molecular biology, biochemistry, and cell biology techniques, and functional genomics and single-cell omics; bioinformatics.

Physical Requirements

Work requires occasionally lifting moderate weight materials, standing, or walking continuously.

Work Environment

Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.

Sensory Acuity

Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.

Why MCW?

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental.
• Along with Flexible Spending options
• 403B Retirement Package
• Competitive Vacation and Paid Holidays offered
• Tuition Reimbursement
• Paid Parental Leave
• Employee & Family Assistance Program (EFAP)
• Pet Insurance
• On campus Fitness Facility, offering onsite classes
• Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.

For a brief overview of our benefits see: Benefits Overview For a full list of positions see: MCW Careers

MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination

The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

About Us

Together, we can build a healthier world. A student, an educator, a scientist and a community leader — alone, they can do many things. Together, the question isn’t what they can do, but what can’t they. The Medical College of Wisconsin (MCW) brings together the most inquisitive, passionate minds in science, medicine, education and community engagement to tackle today’s toughest challenges in health and society. Academic medicine is at the center of where scientists, physicians and students work hand-in-hand with the community to ask the most important questions and fuel the cycle of innovation that shapes the future of medicine. Medical College of Wisconsin The tireless pursuit of knowledge and the power of academic medicine is at the core of everything we do at MCW. Bringing together the world’s top scientists and clinicians, inspired students and invested communities, we are driven to solve the most complex challenges in health and society. With around 1,600 full-time and part-time faculty and approximately 3,500 full-time employees, MCW is home to a diverse group of thought leaders working in collaboration to pioneer pathways to a healthier world and drive a continuous cycle of life-changing discovery.