Postdoctoral Researcher

Boston Children's Hospital; Boston (MA); On-site; USD 60,000 - 80,000; Full time

Job summary

Boston Children's Hospital's Yu Laboratory in the Division of Genetics and Genomics (Harvard Medical School) seeks a highly motivated Postdoctoral Research Fellow to advance neurogenetics and genomic medicine. You will work on interdisciplinary projects combining biology, computation, and clinical translation.

The role emphasizes bioinformatics, neuroscience, and translational genomics, with opportunities to lead independent projects and contribute to grant proposals within a collaborative team

Qualifications

• PhD, MD/PhD, or equivalent in bioinformatics
• Experience with antisense oligonucleotide (ASO) development or RNA-targeting therapeutics is preferred
• Experience with genomic technologies, neurobiological models, or therapeutic development is highly desirable
• Demonstrated ability to work both independently and collaboratively in a multidisciplinary research environment
• Excellent written and verbal communication skills

Responsibilities

• Design and conduct independent research projects related to neurogenetics and genomic medicine
• Apply bioinformatic and genomic techniques to study neurodevelopmental disorders
• Analyze and interpret genomic and experimental data
• Collaborate with multidisciplinary teams across clinical and research programs
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications

Skills

Bioinformatics

Neurogenetics

Collaborative work

Independent work

Communication skills

Education

PhD, MD/PhD, or equivalent in bioinformatics

Tools

ASO development

Job description

Role: Postdoctoral Research Fellow- Yu Laboratory:Division of Genetics and Genomics, Boston Children's Hospital | Harvard Medical School

The Yu Lab at Boston Children's Hospital is seeking a highly motivated and collaborative Postdoctoral Research Fellow to join our interdisciplinary research team. We are particularly interested in candidates with expertise in bioinformatics and neuroscience who are passionate about advancing genomic medicine for neurodevelopmental and rare genetic disorders.

About the Lab

The Yu Lab focuses on autism genetics and translational genomics, integrating genetics, neurobiology, and bioinformatics to understand and treat rare pediatric neurological diseases. The lab is led by Dr. Timothy Yu, Principal Investigator in the Division of Genetics and Genomics at Boston Children's Hospital and Associate Member of the Broad Institute of MIT and Harvard.

Our research spans a broad range of projects, including:

• Computational genomic analysis of large autism cohorts to identify disease-causing genes
• Investigation of genome sequencing applications in newborn screening and neonatal intensive care
• Development of platform approaches for individualized therapies for rare neurogenetic diseases
• Implementation of rapid-turnaround genomic sequencing in the NICU to accelerate diagnosis and treatment
• Development of institution-wide rare disease genomics cohorts to facilitate discovery and clinical translation

The lab is also pioneering individualized genomic medicine using antisense oligonucleotides (ASOs). In 2018, our group developed the world's first fully individualized ASO therapy to treat a young girl with a fatal neurogenetic disorder. Building on this work, we currently have additional n=1 therapeutic programs in preclinical and clinical stages and are collaborating closely with the FDA to establish regulatory pathways for individualized therapies.

Research Environment

The Yu Lab operates at the intersection of genetics, neurobiology, and computational biology, providing a highly collaborative environment at Boston Children's Hospital. Fellows will have opportunities to work with cutting-edge genomic technologies and advanced experimental neurobiological models while contributing to translational efforts that directly impact patient care.

Responsibilities

• Design and conduct independent research projects related to neurogenetics and genomic medicine
• Apply bioinformatic and genomic techniques to study neurodevelopmental disorders
• Analyze and interpret genomic and experimental data
• Collaborate with multidisciplinary teams across clinical and research programs
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications

Qualifications

• PhD, MD/PhD, or equivalent in bioinformatics
• Experience with antisense oligonucleotide (ASO) development or RNA-targeting therapeutics is preferred
• Experience with genomic technologies, neurobiological models, or therapeutic development is highly desirable
• Demonstrated ability to work both independently and collaboratively in a multidisciplinary research environment
• Excellent written and verbal communication skills

Pay Transparency

Exempt Role:

The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting.

Pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors.

BCH offers a comprehensive benefits package that includes flexible schedules, medical/vision/dental coverage, child-care and student-loan subsidies, generous paid time off, a 403(b) retirement plan, commuter and other employee discounts.

Boston Children's Hospital requires influenza vaccination for all employees, unless eligible for a medical or religious exemption.

Boston Children's Hospital is an Equal Opportunity/Affirmative Action Employer; all qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, disability, or other protected status.