Postdoctoral Research on tRNA Epigenetic Modifications

Rnaj; Philadelphia (Philadelphia County); On-site; USD 50,000 - 70,000; Full time

Job summary

A leading research lab is seeking a Postdoctoral Researcher to explore tRNA epigenetic modifications and their role in gene expression and stress responses. The position, based at Thomas Jefferson University, requires a Ph.D. and experience in RNA-seq and high-throughput data analysis. Candidates are encouraged to apply with a strong passion for basic research. This role offers an opportunity to engage in pioneering projects in molecular biology.

Qualifications

• Candidates should have an expected Ph.D. degree.
• Passion for basic research is essential.
• Experience in the mentioned skills is preferred.

Responsibilities

• Conduct research on tRNA epigenetic modifications.
• Explore roles in gene expression and cellular stress.
• Participate in intellectually stimulating lab projects.

Skills

RNA-seq

High-throughput data analysis

Fluorescence microscopy

Cell culture

Molecular biology

Protein enzymology

Nucleic acids research

Mitochondrial research

Education

Ph.D.

Job description

Postdoctoral Research on tRNA Epigenetic Modifications

Created: 09 December 2019

Postdoctoral positions are available in the lab of Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic modifications and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology. We use a synthetic biology approach to determine how modifications impact cell fitness in engineered genomes with synonymous replacement of codons.

Our lab is intellectually stimulating and encouraging global networking. Current projects are:

• Codon-specific translation in response to stress.
• Epigenetics of tRNA in neurodegenerate diseases.

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
Nucleic Acids Res. 46, e37 (2018). PMID: 29361055
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175 (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262

Candidates with an expected Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA‑seq, high‑throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and names and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10 th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480
Email: [e-mail]