Postdoctoral Research on tRNA Epigenetic Biology

Rnaj; Philadelphia (Philadelphia County); On-site; USD 50,000 - 70,000; Full time

Job summary

A research laboratory in Philadelphia is offering a Postdoctoral Research position focusing on tRNA epigenetic biology, evaluating its role in gene expression and cellular stress. Interested candidates with a recent Ph.D. and expertise in RNA-seq, high-throughput analysis, and other molecular biology techniques are encouraged to apply. Application materials include a cover letter, CV, and references. The research program emphasizes cutting-edge molecular biology and significant global networking opportunities.

Qualifications

• Recent Ph.D. in a relevant field.
• Passion for basic research.
• Experience with RNA-seq and data analysis preferred.

Responsibilities

• Conduct research on tRNA epigenetic changes.
• Explore gene expression roles and cellular stress impacts.

Skills

RNA-seq

High-throughput data analysis

Fluorescence microscopy

Cell culture

Molecular biology

Protein enzymology

Nucleic acids research

Mitochondrial research

Education

Ph.D.

Job description

Postdoctoral Research on tRNA Epigenetic Biology

Created: 02 April 2020

Postdoctoral positions are available with Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic changes and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology and central dogma. We use a synthetic biology approach with CRISPR/Cas-edited genomes to determine how modifications in tRNA impact cell fitness at the codon level. Our lab is intellectually stimulating and encouraging global networking.

Current projects are tRNA epigenetic biology:

• In response to environmental stress
• In discovery of new bacterial physiology and antibiotic therapeutics

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
Nucleic Acids Res. 46, e37 (2018). PMID: 29361055
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175 . (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262

Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and names and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10 th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480
Email: [e-mail]