Post Doc

Thomas Jefferson University; United States; On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Tuition assistance

Retirement plans

Medical insurance

Vision insurance

Dental insurance

Disability coverage

Flexible spending accounts

Job summary

Thomas Jefferson University in Philadelphia invites a highly motivated computational biologist to support research on ribothrypsis and co-translational RNA decay, investigating RNA dysregulation in neurodegenerative diseases. The role blends molecular biology, biochemistry, RNA sequencing technologies, and advanced computational approaches.

You will develop and implement bioinformatics tools and pipelines, oversee processing and analysis of next-generation sequencing data, and collaborate across

Qualifications

• PhD in Computational Biology, Bioinformatics, or a related field.
• Proficiency in R and Python; Linux/Unix command line experience.
• Experience with RNA-Seq and Ribo-Seq data and visualization.
• Publication record in relevant fields.
• Strong analytical and collaborative skills.

Responsibilities

• Support ongoing research projects in ribothrypsis and RNA dysregulation.
• Develop and implement bioinformatics tools and pipelines.
• Oversee processing, management, and analysis of NGS data.

Skills

R & Python proficiency

NGS data analysis

Statistical methods

Publication record

Education

PhD in Computational Biology or related field

Tools

ENCODE

UCSC Genome Browser

Ensembl

Bioconductor

NCBI databases

Job description

Job Details A computational biologist position is immediately available in the laboratory of Dr. Fadia Ibrahim in the Department of Biochemistry and Molecular Biology, at Thomas Jefferson University. Our research program is focused on studying the molecular mechanism of a novel co-translational RNA decay process "ribothrypsis” and investigating the role of RNA dysregulation in neurodegenerative diseases. Our research integrates molecular biology, biochemistry, innovative RNA sequencing technologies, and advanced computational approaches. We are seeking a highly motivated computational biologist to support ongoing research projects, develop and implement bioinformatics tools and pipelines, and oversee the processing, management, and analysis of next generation sequencing (NGS) data.

Required Qualifications

• Ph.D. in Computational Biology, Bioinformatics, Computational Sciences, or a related discipline.
• Proficiency in R and Python and in working in Linux/Unix environments with commandline-based bioinformatics tools.
• Experience analyzing and interpreting NGS data, including RNA-Seq and Ribo-Seq, with expertise in data evaluation and visualization (e.g., differential expression, ribosome occupancy, poly(A) tail analysis, and modifications detection).
• Basic knowledge of molecular biology techniques and familiarity with biological data.
• Knowledge of statistical methods and their applications to biological datasets.
• Strong analytical, problem-solving, and quantitative skills, with the ability to collaborate effectively in a multidisciplinary team environment.
• Publication track-record in relevant fields.

Preferred Qualifications

• Familiarity with NGS platforms, including Illumina and Oxford Nanopore Technologies.
• Demonstrated ability to integrate, mine, and analyze diverse large-scale biological datasets.
• Experience with commonly used bioinformatics resources, tools, and databases, including ENCODE, UCSC Genome Browser, Ensembl, Bioconductor, and NCBI databases.
• Experience managing computational servers and data storage and backup.
• Ability to formulate and develop scientific hypotheses that support ongoing research.
• Strong organizational, written, and verbal communication skills.

Work Shift: Workday Day (United States of America). Worker Sub Type: Regular Employee Entity Thomas Jefferson University. Primary Location Address: 1020 Locust Street, Philadelphia, Pennsylvania, United States of America.

Benefits

• medical (including prescription)
• supplemental insurance
• dental
• vision
• life and AD&D insurance
• short- and long-term disability
• flexible spending accounts
• retirement plans
• tuition assistance
• voluntary benefits

Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service.

All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps), have access to medical (including prescription) insurance.

Jefferson is committed to providing equal educational and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status.

Jefferson encourages its employees to expand their knowledge and develop their careers through growth opportunities and continuing education. With a long standing history, Jefferson has been advancing the medical field from the heart of Center City Philadelphia for nearly 200 years. Our Mission, We Improve Lives, expands to every corner of the organization. From our weekly farmer’s market, to our new Jefferson Accelerator Zone for innovation, our employees’ passion for the community is evident by the daily gestures towards our patients, students and each other.