Postdoctoral Research Fellow (Miraldi) Computational Systems Biology

Cincinnati Children's; Cincinnati (OH); On-site; USD 60,000 - 80,000; Full time

Job summary

Cincinnati Children's is seeking a computational research fellow to develop mathematical models of the immune system through collaborative approaches with experimental immunologists. This full-time position involves designing experiments and analyzing complex data to drive new insights into immune-cell function.

The ideal candidate will hold a Ph.D. or equivalent in a relevant discipline and possess a strong background in computational biology or a related field. The role offers a unique opportunity to contribute to impactful research in pediatric health.

Qualifications

• Ph.D. in a related discipline, MD, or equivalent degree.
• Experience in a quantitative discipline is preferred.

Responsibilities

• Design, execute, and record analysis and experiments.
• Draft and edit scientific reports and journal articles.
• Reproduce and improve techniques used in the department.
• Assist in preparing grant applications and maintaining budget.
• Provide day-to-day functional leadership for a team.
• Develop new courses and deliver training to new employees.

Education

Ph.D. in related discipline, MD, or equivalent degree

PhD in Computer Science, Physics, Biomedical Informatics, Bioinformatics, Epidemiology, Biostatistics or similar disciplines

Experience in a related discipline

Job description

Dr. Miraldi’s Immuno-Engineering Laboratory seeks a computational research fellow to build mathematical models of the immune system in vivo. These models will be constructed from cutting‑edge, high‑dimensional, immune‑system measurements (e.g., single‑cell genomics, chromatin state, proteomics). Our mathematical modeling frameworks span mechanistic (e.g., dynamic gene regulatory networks) to deep learning (e.g., prediction of cellular epigenomes from DNA sequence). Situated at Cincinnati Children’s Hospital, we are dedicated to the design of computational methods and systems‑immunology studies that will ultimately improve the health of children. Through close collaboration with our physician and experimental colleagues, we iteratively test and refine our models, so that the models yield novel insights into immune‑cell function and ultimately guide new therapeutic strategies in the context of autoimmunity, infectious disease and cancer. The ideal candidate will collaborate closely with experimental immunologists, physicians and other computational biologists. The team will design and execute hybrid computational‑experimental strategies that push the boundaries of both immunology and computational biology.

Job Responsibilities

• Perform analysis and experiments - Design, execute, and record analysis and experiments; apply standard scientific protocols to research, and improve current methods and evaluate innovative techniques. Develop and implement human subject research protocols, vertebrate animal research protocols and design experimental procedures and documentation in accordance with the relevant laws and regulations. Prepare, clean and analyze data. Maintain optimal protocol and accuracy by conducting regular quality and reproducibility checks.
• Communicate results/findings - Draft, write, and edit scientific reports, papers, journal articles, and abstracts. Present information on research and department work to others at department meetings, journal clubs, and seminars. Present results and discuss relevant insights with Faculty and provide useful recommendations and analysis.
• Innovate and advance departmental capabilities - Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current analysis/experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all analysis and experiments. Develop, set‑up, and verify new procedures in the department. Standardize and establish new published procedures; evaluate innovative techniques. Develop new protocols; design formats. Maintain an integral role in the department’s meetings, presentations, and publications. Troubleshoot and correct erroneous results or problems with department software/equipment. Maintain and repair software/equipment; monitor proper use by personnel.
• Financial/Budgeting - Assist in preparing grant applications. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve, and initiate check requests; track funding, maintain accurate balance, and resolve any discrepancies.
• Staff Leadership - May provide day‑to‑day functional leadership for a team or directly manage a minimal number of support staff. Establishes team goals. Gives input into, and performs employee performance reviews. Oversees and guides work assignments. Serves as the functional expert and provides guidance to the team.
• Education and Training - May serve as course master and develop new courses at the undergraduate and graduate level, including appropriate plans for evaluating student performance; may deliver lectures as a guest lecturer in courses organized by other faculty. Assist in the training of new employees. Serve as a resource and/or mentor to coworkers. Assist in the development and presentation of department training. Identify training needs and provide necessary coaching.

Job Qualifications

• Ph.D. in related discipline, MD, or equivalent degree
• Preferred: PhD in Computer Science, Physics, Biomedical Informatics, Bioinformatics, Epidemiology, Biostatistics or other similar quantitative disciplines
• Preferred: Experience in a related discipline

Primary Location: Location S

Schedule: Full time

Shift: Day (United States of America)

Department: Immunobiology

Employee Status: Regular

FTE: 1

Weekly Hours: 40

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability