Postdoctoral Research Fellow - D'Andrea Lab

Dana-Farber Cancer Institute (DFCI); Boston (MA); On-site; USD 72,000 - 76,000; Full time

Job summary

Dana-Farber Cancer Institute in Boston, MA seeks a Postdoctoral Research Fellow to join the D’Andrea Lab. The role focuses on the molecular basis of genomic stability and DNA repair mechanisms in human cancers, with access to advanced molecular biology tools and collaborations across disciplines.

The incumbent will design and execute experiments, use CRISPR/Cas9 and mass spectrometry, analyze data, and contribute to publications and grant applications within a dynamic team.

Qualifications

• PhD or MD in Molecular Biology, Cell Biology, Biochemistry, Genetics, or a related field.
• Experience with mammalian cell culture, protein purification, and molecular cloning.
• Excellent communication skills and ability to publish in peer-reviewed journals.

Responsibilities

• Design and conduct experiments related to DNA repair pathways, replication fork stability, and ubiquitin signaling.
• Use advanced techniques such as CRISPR/Cas9 gene editing, protein biochemistry, mass spectrometry, and live-cell imaging.
• Analyze data, interpret results, and present findings at internal and external scientific meetings.
• Collaborate with multidisciplinary teams, including medicinal chemists and clinical researchers.
• Contribute to manuscript writing and grant applications.
• Mentor junior team members and contribute to the overall research environment.

Skills

DNA repair

Cancer biology

Mammalian cell culture

Molecular cloning

Protein purification

CRISPR/Cas9

Mass spectrometry

Live-cell imaging

Education

PhD/MD required

Genetics/biochemistry background

Tools

CRISPR/Cas9

Mass spectrometry

Protein purification

Molecular cloning

Job description

Postdoctoral Research Fellow - D'Andrea Lab

Dana-Farber Cancer Institute

Boston, MA

Full Time

Overview

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Position Summary

The D'Andrea lab investigates chromosome instability and susceptibility to cancer. Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by germline or somatic mutation, leads to genomic instability, cellular sensitivity to ionizing radiation, and defective cell cycle checkpoints and DNA repair. These pathways are often disrupted in cancer cells, accounting for the chromosome instability and increased mutation frequency in human tumors. We are seeking a highly motivated and talented Postdoctoral Research Fellow to join a dynamic team investigating the molecular basis of genomic stability and DNA repair mechanisms in human cancers. The candidate will work in a cutting-edge research environment with access to advanced molecular biology tools and technologies.

Key Responsibilities

• Design and conduct experiments related to DNA repair pathways, replication fork stability, and ubiquitin signaling.
• Use advanced techniques such as CRISPR/Cas9 gene editing, protein biochemistry, mass spectrometry, and live-cell imaging.
• Analyze data, interpret results, and present findings at internal and external scientific meetings.
• Collaborate with multidisciplinary teams, including medicinal chemists and clinical researchers.
• Contribute to manuscript writing and grant applications.
• Mentor junior team members and contribute to the overall research environment.

Qualifications

• PhD or MD in Molecular Biology, Cell Biology, Biochemistry, Genetics, or a related field.
• Strong background in DNA repair, cancer biology, or chromatin biology is preferred.
• Experience with mammalian cell culture, protein purification, and molecular cloning.
• Excellent communication skills and ability to work both independently and in a team-oriented environment.
• Demonstrated ability to publish in peer-reviewed journals.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusiveenvironment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionateprofessionals, neither do we.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

Pay Transparency Statement

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$72,000.00 - $76,385.00