Postdoctoral Research Fellow

Mass General Physicians Organization; Boston (MA); On-site; USD 55,000 - 75,000; Full time

Job summary

The Mass General Physicians Organization in Boston is seeking a highly motivated Postdoctoral Research Fellow to advance research in Familial Dysautonomia. The successful candidate will leverage skills in molecular biology and gene editing while working collaboratively with our team.

Key responsibilities include conducting in vivo studies, analyzing data, and mentoring junior members. A doctoral degree is essential, with a preference for a Ph.D. in relevant fields. This role offers a chance to work within the vibrant MGH/Harvard/Broad Institute ecosystem.

Qualifications

• Experience in gene editing and RNA biology.
• Collaboration with internal and external researchers.
• First (or co-first) author of peer-reviewed scientific publications.

Responsibilities

• Design and conduct in vivo efficacy studies.
• Perform RNA/protein quantification and splicing analysis.
• Lead development of therapeutic delivery and molecular assays.
• Mentor junior lab members and prepare manuscripts.

Skills

Molecular biology techniques

Genetic methodologies

Cell culture experience

Microscopy imaging techniques

Histological techniques

Excellent English communication skills

Education

Doctoral Degree

Ph.D. in neuroscience, molecular biology, genetics, or a related field

Job description

Please send your CV/Resume, Cover Letter and References directly to: Dr. Elisabetta Morini [e-mail] for this position. A linked application is not available.

The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease.

This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes.

We are seeking a creative, independent, and collaborative scientist with a strong background in molecular neuroscience, gene editing, RNA biology, or neurogenetics. Experience working with mouse models, including behavioral assays and molecular analysis of tissues, is highly desirable.

This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state-of-the-art resources and a vibrant scientific community.

Duties and responsibilities:

• Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
• Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.
• Lead the development and optimization of therapeutic delivery and molecular assays.
• Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications.

Education:

Minimum Required: Doctoral Degree

Experience:

Required: Doctoral degree

Preferred: Ph.D. in neuroscience, molecular biology, genetics, or a related field.

Desired skills and competencies:

• Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting)
• Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing
• Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization
• Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.
• Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques
• Histological and immune-histochemical techniques.
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team

Interested applicants should submit their CV/Resume, Cover Letter and References to: Dr. Elisabetta Morini [e-mail]

Please do not apply through this link.

Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.