Postdoctoral Research Associate - Genetics

Washington University in St. Louis; St. Louis (MO); On-site; USD 58,000 - 72,000; Full time

Job summary

Washington University in St. Louis seeks a Postdoctoral Researcher to join a multidisciplinary program focused on genomic and molecular mechanisms underlying chromosome 9p disorders. Under PI Dr.

Tychele Turner, you will generate, analyze, and interpret genomic and multi-omic data and relate findings to clinical phenotypes. The position provides advanced training and mentorship at the interface of human genomics and functional biology while supporting ongoing discovery and the successful

Qualifications

• Ph.D. or equivalent doctoral degree required by start date.
• Experience with genomic datasets, sequencing data analysis, and variant interpretation.
• Experience with mammalian cell culture and molecular biology techniques.
• Strong record of peer-reviewed publications and presentations.
• Interest in human genomics, rare diseases, and chromosome 9p biology.

Responsibilities

• Assist in planning experiments, interpreting findings, and preparing manuscripts.
• Design and perform molecular biology and functional genomics experiments to study chromosome 9p disorders.
• Analyze and integrate genomic and multi-omic datasets with clinical phenotypes.
• Collaborate with multidisciplinary teams and mentor junior staff as appropriate.
• Maintain compliant research records and adhere to university policies.

Skills

Genomic data analysis

Bioinformatic analysis

CRISPR/Cas9 techniques

Induced pluripotent stem cells (iPSCs)

Scientific writing

Collaborative research

Education

Ph.D. in Genetics, Molecular Biology, Cell Biology, Biomedical Sciences, Human Genetics, or related field

Tools

Hi-C

Genome sequencing

PCR/qPCR

Cell culture

Data visualization

Job description

The Postdoctoral Researcher will support a multidisciplinary research program focused on understanding the genomic and molecular mechanisms underlying 9p-related syndromes. Under the supervision of the Principal Investigator (PI) Dr. Tychele Turner, the fellow will contribute to multiple project aims by generating, analyzing, and interpreting genomic and multi-omic datasets; integrating genomic findings with clinical phenotypes; and supporting functional studies to evaluate relevant genes and variants associated with chromosome 9p disorders. The Postdoc will work closely with the PI and collaborate with multidisciplinary research and clinical teams to advance gene discovery and elucidate disease mechanisms. This position provides advanced training and mentorship at the interface of human genomics, rare disease research, and functional biology while supporting the successful execution of the funded research program.

Job Description

Primary Duties & Responsibilities:

Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.

Trains under the supervision of a faculty mentor including (but not limited to):

• Assist with grant preparation and reporting.
• Collaborate with the Principal Investigator and multidisciplinary research team to plan experiments, interpret findings, prepare manuscripts, present research findings, and contribute to grant-related activities.
• Assist in the design of research experiments. Design, conduct, and optimize molecular biology and functional genomics experiments to investigate the molecular mechanisms underlying chromosome 9p-related syndromes, including validation of relevant genes and variants using appropriate cellular and molecular approaches.
• Analyze, interpret, and integrate genomic and multi-omic datasets with clinical phenotype information to identify and prioritize relevant genes, variants, and disease mechanisms.
• Maintain conformity with ethical standards in research.
• Maintain accurate research records, prepare reports, ensure compliance with laboratory and institutional policies, and contribute to overall laboratory operations.
• Engage in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Mentor graduate, undergraduate, and/or research staff as appropriate, while fostering a collaborative, respectful, and inclusive laboratory environment.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Location

ST. LOUIS, MO 63110

Education:

Required Qualifications

Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.

Preferred Qualifications:

More About This Job

• Ph.D. in Genetics, Molecular Biology, Cell Biology, Biomedical Sciences, Human Genetics, or a closely related life sciences field by the start date.
• Experience with genomic datasets, including sequencing data analysis and variant interpretation, or a willingness to develop these skills through training.
• Experience with mammalian cell culture and molecular biology techniques (e.g., DNA/RNA isolation, PCR, qPCR, cloning, CRISPR/Cas9, Hi-C, or related methods).
• Experience in human genetics, rare disease research, or chromosome biology.
• Experience with functional validation of candidate genes or variants using cellular or molecular approaches.
• Familiarity with next-generation sequencing data, copy number variants (CNVs), structural variants, or genotype-phenotype correlation analyses.
• Experience with induced pluripotent stem cells (iPSCs), organoids, animal models, or other disease modeling systems.
• Evidence of peer-reviewed publications and scientific presentations.
• Interest in developing expertise at the interface of human genomics, functional biology, and rare genetic disorders, including chromosome 9p-related syndromes.

Skills:

Bioinformatic Analysis, Collaboration, Computational Analysis, Data Analysis, Data Interpretations, DNA Sequencing, Experimentation, Gene Deletions, Gene Duplication, Genome Sequencing, Human Genetics, Induced Pluripotent Stem Cell (IPSC), Laboratory Operations, Laboratory Techniques, Messenger RNA, Neuroscience, Researching, Results Reporting, Scientific Writing

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email [e-mail] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.