Postdoctoral Position: Red Blood Cell Immunobiology

Upenn; Philadelphia (Philadelphia County); Hybride; USD 65 000 - 85 000; Plein temps

Résumé du poste

University of Pennsylvania seeks a postdoctoral fellow to pursue RBC-based liquid biopsy research. You will lead studies using tumor–RBC co-culture systems, preclinical models, and clinical specimens to define rtDNA mechanisms and detection strategies.

The role emphasizes assay development, analytical performance, and translational potential across oncology indications, with mentorship and collaboration across immunology, hematology, bioengineering, and clinical investigation.

Qualifications

• Ph.D., M.D., or M.D./Ph.D. in cancer biology, molecular biology, genomics, bioengineering, hematology, immunology, or related discipline.
• Strong record of scientific accomplishment with translational cancer research or biomarker development.
• Experience with molecular and cellular biology techniques (PCR, NGS, flow cytometry) desirable.

Responsabilités

• Lead studies integrating tumor–RBC co-culture systems, preclinical models, and clinical specimens.
• Develop and optimize molecular assays for mutation detection and rtDNA analysis.
• Assess analytical sensitivity, specificity, and feasibility of RBC-based liquid biopsy approaches.
• Collaborate with academic and industry partners to advance diagnostic technologies.

Connaissances

PCR

digital PCR

NGS

flow cytometry

biomarker analysis

Formation

PhD, MD, or MD/PhD in relevant field

Outils

Genomics

Biostatistics

Description du poste

University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral

Location

Perelman School of Medicine at the University of Pennsylvania

Description

The Mangalmurti Laboratory, in the Department of Medicine's Divison of Pulmonary, Allergy and Critical Care,invites applications for a postdoctoral position focused on evaluating red blood cells (RBCs) as a novel liquid biopsy platform for cancer detection and disease monitoring. This industry-sponsored project will investigate the biological basis, analytical performance, and translational potential of RBC-associated tumor DNA (rtDNA) as a new substrate for precision oncology applications. The laboratory recently discovered that RBCs rapidly acquire and retain tumor-derived DNA, revealing an unexpected role for RBCs in cancer biology and liquid biopsy. Emerging data suggest that RBC-associated tumor DNA may provide a sensitive and complementary source of tumor-derived genetic material that can overcome some of the limitations of conventional plasma-based approaches.

The successful candidate will lead studies integrating in vitro tumor–RBC co-culture systems, preclinical cancer models, and clinical specimens from patients with cancer to define the mechanisms of rtDNA acquisition, persistence, and detection. The project will include development and optimization of molecular assays for mutation detection, evaluation of analytical sensitivity and specificity, and assessment of the feasibility of RBC-based liquid biopsy approaches across multiple oncology indications.

This position offers a unique opportunity to work at the intersection of cancer biology, liquid biopsy technology, and translational medicine while helping establish an entirely new diagnostic paradigm. The fellow will collaborate closely with academic and industry partners and will contribute to the advancement of RBC-based technologies for cancer detection, disease monitoring, and precision oncology.

Postdoctoral fellows receive close mentorship with an emphasis on developing scientific independence, rigorous experimental design, and career development. Trainees are encouraged and supported to pursue their own research directions, obtain independent funding, and engage in interdisciplinary collaborations spanning immunology, hematology, bioengineering, and clinical investigation. The laboratory is embedded within a strong research environment with access to outstanding core facilities and institutional career development resources.

Training Environment and Mentorship

The postdoctoral fellow will receive close mentorship with an emphasis on scientific rigor, experimental design, translational research, and career development. The fellow will have the opportunity to lead an industry-sponsored research program aimed at evaluating the feasibility of red blood cell–based liquid biopsy technologies for oncology applications. Training will encompass biomarker discovery, assay development, translational study design, and the generation of data needed to support future clinical and commercial development.

The fellow will work within a highly collaborative environment that integrates cancer biology, hematology, genomics, bioengineering, and clinical investigation. Opportunities will be available to interact with industry partners, participate in multidisciplinary project teams, and gain exposure to the scientific, regulatory, and strategic considerations involved in advancing novel diagnostic technologies from discovery toward clinical implementation.

The laboratory is embedded within a premier academic medical center and provides access to outstanding core facilities, including genomics, bioinformatics, flow cytometry, imaging, and biostatistics resources. Fellows are encouraged to develop scientific independence, publish their findings in high-impact journals, present their work at national and international meetings, and pursue career paths in academia, biotechnology, or the pharmaceutical industry.

Qualifications

Applicants must hold a Ph.D., M.D., or M.D./Ph.D. in cancer biology, molecular biology, genomics, bioengineering, hematology, immunology, or a related discipline. Candidates should have a strong record of scientific accomplishment and a demonstrated interest in translational cancer research, biomarker development, liquid biopsy technologies, or precision oncology.

Experience with molecular and cellular biology techniques, including PCR, digital PCR, next-generation sequencing, circulating biomarker analysis, flow cytometry, or related methodologies is desirable. The ideal candidate will be highly motivated, intellectually curious, and excited to contribute to the development of red blood cell–based liquid biopsy approaches for cancer detection and disease monitoring.

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.