Postdoctoral GPCR Structure & Computational Biophysics

University of North Carolina - Chapel Hill; Elkins Hills (NC); On-site; USD 54,000 - 74,000; Full time

Job summary

University of North Carolina at Chapel Hill seeks a Postdoctoral Research Associate to advance GPCR signaling studies and contribute to therapeutic discovery. The role focuses on 5-HT receptor systems, integrating molecular pharmacology, structural biology, and computational biophysics to reveal atomistic mechanisms behind ligand efficacy.

The successful candidate will perform protein expression, purification, cryo-EM analyses, and collaboration with an interdisciplinary team to translate

Qualifications

• PhD in a relevant field with strong publication record.
• Experience in protein expression and purification.
• Hands-on cryo-EM and structural biology experience.
• Familiarity with mammalian cell culture is a plus.

Responsibilities

• Carry out GPCR-focused molecular pharmacology and structural biology experiments.
• Apply cryo-EM to define receptor–ligand interactions.
• Develop computational workflows (MD, docking) for mechanistic insights.
• Collaborate across disciplines to advance therapeutic discovery.

Skills

Protein expression

Cryo-EM

Molecular cloning

PCR

Mammalian cell culture

Education

PhD

Tools

Cryo-EM software

Job description

University of North Carolina at Chapel Hill seeks a Postdoctoral Research Associate to advance GPCR signaling studies and contribute to therapeutic discovery. The role focuses on 5-HT receptor systems, integrating molecular pharmacology, structural biology, and computational biophysics to reveal atomistic mechanisms behind ligand efficacy.

The successful candidate will perform protein expression, purification, cryo-EM analyses, and collaboration with an interdisciplinary team to translate