Lead GPCR Single-Molecule Biophysics Postdoc

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 55,000 - 70,000; Full time

Job summary

St. Jude Children\u2019s Research Hospital is seeking a Postdoctoral Research Associate in the Blanchard Laboratory, Department of Structural Biology, to investigate GPCR signaling fidelity at the single-molecule level using molecular biology, biochemistry of membrane proteins, and quantitative biophysical approaches.

The ideal candidate will design experiments, analyze data, and present findings with minimal supervision, mentoring students and collaborating across institutions.

Qualifications

• Ph.D in life science or other physical science.
• 0-3 years of Post-PhD experience.
• Prior experience in GPCR signaling studies and/or single-molecule fluorescence analyses is highly preferred.
• Direct experience with isolation and functional characterization of GPCRs and their signaling partners (G-proteins, arrestins, GPCR kinases, etc.) is strongly preferred.

Responsibilities

• Lead the experimental design, execution, and data analysis of biophysical studies characterizing GPCR structural dynamics with in vivo downstream signaling response.
• Engineer and isolate high-quality, homogeneous samples of GPCRs and signaling partners for ensemble and single-molecule analytical assays.
• Expand your technical skillset through expert-led training in smFRET imaging to perform experiments, analyze complex datasets, and develop quantitative models to explain GPCR signaling mechanisms.
• Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
• Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
• Train and mentor graduate students, postdocs and visiting scientists.
• Instruct other staff in basic laboratory techniques and procedures.

Skills

Molecular biology

Biochemistry

Membrane proteins

Quantitative biophysics

Computational biology

GPCR signaling

Single-molecule

Leadership

Education

Ph.D in life science

Tools

smFRET imaging

Fluorescence microscopy

Job description

St. Jude Children\u2019s Research Hospital is seeking a Postdoctoral Research Associate in the Blanchard Laboratory, Department of Structural Biology, to investigate GPCR signaling fidelity at the single-molecule level using molecular biology, biochemistry of membrane proteins, and quantitative biophysical approaches.

The ideal candidate will design experiments, analyze data, and present findings with minimal supervision, mentoring students and collaborating across institutions.