Postdoctoral Fellow - Zhang Lab

Cold Spring Harbor Laboratory Inc.; New York (NY); On-site; USD 67,000 - 82,000; Full time

Benefits offered by this job

Health benefits

Retirement plans

Paid time off

Wellness programs

Job summary

Cold Spring Harbor Laboratory in New York invites applications for a fully funded postdoctoral fellowship. The lab studies normal and malignant hematopoietic stem/progenitor cells and how metabolites shape the tumor microenvironment and genetic effectors.

The successful candidate will use CRISPR/Cas, metabolomics, optogenetics, and fiber photometry to uncover mechanistic insights, identify drug targets, and develop novel therapeutics for hematologic malignancies.

Qualifications

• PhD in biomedical sciences required.
• Experience with flow cytometry and metabolomics analysis or optogenetics and fiber photometry.

Responsibilities

• Investigate roles of metabolites and genetic effectors in hematopoietic malignancies using CRISPR/Cas and metabolomics.
• Identify drug targets and mechanisms to understand environmental signals on blood cell development and cancer.
• Contribute to development of innovative therapeutics for hematopoietic malignancies.

Skills

Molecular biology

Cell biology

Animal model

Cancer research

Flow cytometry

Metabolomics

Optogenetics

Fiber photometry

Education

PhD in biomedical sciences

Job description

Worker Type:

Post Docs

Job Description:

Dr. Lingbo Zhang's Lab at Cold Spring Harbor Laboratory focuses on both basic science and translational medicine of hematologic malignancies. The research of the Lab centers on normal and malignant stem and progenitor cells in the hematopoietic system and decodes the role of metabolites, including micronutrients and neurotransmitters, in the tumor microenvironment and their genetic effectors in regulating hematologic malignancies.

This is a fully funded postdoctoral fellowship available to investigate the roles of these critical metabolites and their genetic effectors in hematopoietic malignancies and develop novel therapeutic strategies.

Position Responsibilities:

The Lab utilizes a combination of CRISPR/Cas functional genomics and metabolomics as well as optogenetics and fiber photometry approaches to systematically uncover the critical metabolites and their genetic effectors, including receptors and metabolic enzymes, to reveal mechanistic insights of and identify key drug targets for hematologic malignancies. The ultimate goal is to understand how environmental signals such as diets and nervous system activities modulate blood cell development and cancers. Based on these basic mechanistic insights, the Lab is building innovative therapeutics to treat hematopoietic malignancies that are currently without effective therapeutic options.

Position Requirements:

• Education: Applicants should hold a PhD in biomedical sciences
• Experience/Skills: Ideal candidates should have strong research backgrounds in molecular and cellular biology, animal model and cancer research, and experiences with flow cytometry and metabolomics analysis or optogenetics and fiber photometry..

Compensation and Benefits:

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL Benefits & Postdoctoral Landing sites to learn more. The salary for this role is $74,300.00 per annum. The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).

Environment:

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program.We believe that science is for everyone and our researchers have a wide variety of backgrounds.

CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status. VEVRAA Federal Contractor

For more information about CSHL, please visit us at www.cshl.edu.