Postdoctoral Fellow - Yeh Lab

Cold Spring Harbor Laboratory Inc.; New York (NY); On-site; USD 66,000 - 81,000; Full time

Job summary

The Yeh Laboratory at Cold Spring Harbor Laboratory (CSHL) Cancer Center is recruiting a Postdoc Fellow to advance drug discovery and chemical biology efforts. The project will focus on developing and validating novel Targeted Protein Degradation (TPD) molecules to target undruggable proteins in cancer biology.

The lab emphasizes multidisciplinary collaboration and access to state-of-the-art facilities, including a new Chemistry for Biology initiative.

Qualifications

• PhD candidates with strong organic synthesis, macrocycle and peptide/protein chemistry or chemical biology experience
• Experience or coursework in medicinal chemistry is highly desirable
• PhD holders or candidates expected to graduate in 2024 are encouraged to apply

Responsibilities

• Develop and validate novel TPD molecules to target undruggable proteins
• Collaborate within the Yeh Lab and Cancer Center to advance drug discovery projects

Skills

Organic synthesis

Macrocycle chemistry

Peptide chemistry

Protein chemistry

Chemical biology

Education

Ph.D. in life science or chemistry

Job description

Worker Type

Post Docs

Job Description

A Postdoc Fellow position is available at The Yeh Laboratory at CSHL Cancer Center Yeh Lab Site We are recruiting new members passionate about drug discovery and chemical biology. Our lab is working to understand the molecular mechanisms leading to efficient elicitation of tumor vulnerability for potent cancer targeting. We develop Targeted Protein Degradation (TPD) therapeutic strategies to abrogate or rewire cancer cell signaling. We have recently established a new discovery platform to expand the landscape of TPD E3 ligases and targeting modalities beyond conventional small molecules(Genes & Development 2022 36:1031-1042.; Genes & Development 2023 37: 1-17). For this open position, the project direction will be focused on continuing developing and validating novel TPD molecules to target undruggable proteins.

The Yeh Lab is a highly-collaborative environment with state-of-the-art facilities and expertise in biotherapeutics engineering and chemical biology. We feature multidiscipline approaches to tackle scientific questions. The Yeh Lab also engages in several close collaborations with other research groups at the Cancer Center. This postdoc fellow will be part of a new Chemical Biology initiative at CSHL and will enjoy the highly intellectual and collaborative interactions at CSHL, including accessing CSHL conferences on cutting edge scientific discoveries.

PhD candidates are encouraged to apply. Candidates with expertise in organic synthesis, peptide/ natural product/macrocycle chemistry, or chemical biology related to medicinal chemistry are highly desired.

Position Requirements

EDUCATION: Successful applicants should possess a Ph.D. degree or equivalent in a life science or chemistry discipline at the time of appointment.

Experience/Skill: Expertise in organic synthesis, macrocycle and peptide/protein chemistry or chemical biology are strongly desired. PhD candidates expecting to complete their degree in 2024 are encouraged to apply. This postdoc fellow will also be part of a new Chemistry for Biology initiative at CSHL.

Compensation and Benefits

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL Benefits , Postdoctoral Landing & Postdoctoral Fellow Stipend Schedule sites to learn more. The salary for this role is $73,400.00 per annum. The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).

Environment

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program.We believe that science is for everyone and our researchers have a wide variety of backgrounds.

CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status. VEVRAA Federal Contractor

For more information about CSHL, please visit us at www.cshl.edu.