Postdoctoral Fellow — Nephrology Kidney Disease Research

Mount Sinai Morningside; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Morningside invites applications for a postdoctoral researcher in Medicine/Nephrology to study TENM3 in diabetic kidney disease. The project uses in vitro podocyte cultures and in vivo mouse models to elucidate disease mechanisms at 1468 Madison Avenue, Annenberg 23-16, New York, NY 10029.

The candidate should have MD or basic science training with experience in bench work and animal studies, and a strong interest in nephrology and translational research.

Qualifications

• Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).
• Experience in medical research and know how to perform basic bench work and animal studies.

Responsibilities

• Perform in vitro cell cultures of glomerular podocytes and test whether overexpression or knockdown of TENM3 affects podocyte function.
• Generate mutant constructs of TENM3 to mimic human variants; perform qPCR and Western blot analysis of TENM3 expression.
• We have generated transgenic mouse models with overexpression or knockdown of TENM3 in podocytes to test kidney injury.
• Techniques include cell culture, western blot, qPCR, genotyping of mice, mouse breeding, kidney histology analysis, immunostaining, and assessment of urine albumin and renal function.

Skills

Nephrology knowledge

Bench work

Animal studies

Research experience

Education

MD or PhD in a related field

Tools

qPCR

Western blot

Genotyping

Histology

Job description

Mount Sinai Morningside invites applications for a postdoctoral researcher in Medicine/Nephrology to study TENM3 in diabetic kidney disease. The project uses in vitro podocyte cultures and in vivo mouse models to elucidate disease mechanisms at 1468 Madison Avenue, Annenberg 23-16, New York, NY 10029.

The candidate should have MD or basic science training with experience in bench work and animal studies, and a strong interest in nephrology and translational research.