Post Doctoral Fellow-MSH-12908-021

Mount Sinai Health System; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Health System in New York, NY, invites a postdoctoral researcher to investigate TENM3 in diabetic kidney disease within the Medicine/Nephrology lab. The project uses in vitro podocyte cultures and transgenic mice to define TENM3's role in glomerular injury.

The candidate should have MD-equivalent or basic science training and experience in bench work and animal studies; nephrology background is preferred. Administrative contact available for inquiries.

Qualifications

• Postdoc should have medical training (MD equivalent) or basic science training.
• Familiar with kidney disease pathogenesis (Nephrology training).
• Experience with bench work and animal studies.

Responsibilities

• Perform in vitro cell cultures of glomerular podocytes and test TENM3 effects.
• Generate TENM3 mutant constructs and analyze expression by qPCR and Western blot.
• Use transgenic mouse models to assess podocyte injury in kidney disease.
• Conduct kidney histology, immunostaining, and urine/renal function measurements.

Skills

Bench work

Animal studies

Medical research

Education

MD equivalent

Nephrology training

Job description

Description

Department:

Medicine/Nephrology

Physical work location:

1468 Madison Avenue, Annenberg 23-16, New York, NY 10029

Name PI or Supervisor:

John Cijiang He

Web link to Lab:

https://labs.icahn.mssm.edu/helab/meet-the-team/

Web link to Department:

https://icahn.mssm.edu/about/departments-offices/medicine/nephrology

Administrative Contact:

Irene Beaulieu; email: [e-mail]

Responsibilities

Background and Description of Research Project:

Diabetic kidney disease is the number one cause of kidney failure in the USA as well as in the world. Its underlined pathogenesis remains unclear and the treatment is limited. We have been using systems biology approach to study its pathogenesis in order to identify potential new drug targets to treat this disease. Recently, we identified TENM3 as a key molecule involving in glomerular podocyte injury in diabetic kidney disease. The current project will focus on the role of TENM3 in the pathogenesis of diabetic kidney disease. We will use in vitro assays and in vivo animal models to confirm the critical role of TENM3 in podocyte injury in diabetic kidney disease.

Technical Duties (include Any Protocols)

• Perform in vitro cell cultures of glomerular podocytes and test whether overexpression or knockdown of TENM3 affects podocyte function.
• We will generate mutant constructs of TENM3 to mimic human variants. We will perform qPCR and Western blot analysis of TENM3 expression.
• We have generated transgenic mouse models with overexpression or knockdown of TENM3 in podocytes. We will test whether these mice develop more or less kidney injury.
• Techniques include cell culture, western blot, qPCR, genotyping of mice, mouse breading, kidney histology analysis, immunostaining, determination of urine albumin and renal function.

Qualifications

Educational and other Requirements for the position:

Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).

Experience Required:

Candidate should have basic training in medical research and know how to perform basic bench work and animal studies.

Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well‑being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About The Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high‑quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint‑venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.