Postdoctoral Fellow

Harvard University; Cambridge (MA); On-site; USD 60,000 - 90,000; Full time

Job summary

Harvard University seeks a qualified candidate to join their lab focused on cutting-edge techniques for visualizing cellular structures. Responsibilities include further developing cryo-vitrification methods and applying new technologies to explore cell biology, particularly around G-protein-coupled receptors.

The ideal candidate will possess skills in biophysical instrumentation, optical imaging, and knowledge of biomolecular condensates.

Qualifications

• Experience with optical and mechanical design for instrumentation development.
• Familiarity with single-molecule fluorescence and FRET.
• Understanding of cell and molecular biology principles.

Responsibilities

• Develop methods for visualizing cellular organization.
• Apply new technologies to fundamental questions in cell biology.

Skills

Biophysical instrumentation development

Optical imaging

Biophysics of cell signaling

Cryo-vitrification

Microfluidics

Electron microscopy

Job description

Department/Area: Molecular and Cellular Biology / Applied Physics / SEAS

Position Description

Our lab is developing a series of cutting‑edge methods to visualize cellular organization. As one example, we are using time‑resolved cryo‑vitrification (both cryo‑plunging and high‑pressure freezing) to visualize the nanoscale dynamics of cellular response to stimuli. In another direction, we are developing multicolor electron microscopy using the principle of “cathodoluminescence” – emission of light triggered by excitation with an electron beam. The advertised position involves further development of these and related methods as well as applications of these new technologies to address questions in the fundamental cell biology of transmembrane signaling through G‑protein‑coupled receptors and the formation of biomolecular condensates.

Basic Qualifications

• Biophysical instrumentation development: optical and mechanical design, simulation, development and control
• Optical imaging; Single‑molecule fluorescence and FRET; Lasers; Pump‑probe experiments
• Biophysics of cell signaling and stress response; Biomolecular condensates; G‑protein‑coupled receptors (GPCRs); Cell and molecular biology
• Cryo‑vitrification via cryo‑plunging and high‑pressure freezing; Time‑resolved freezing
• Microfluidics; design, simulation, prototyping, fabrication and testing of fluidic devices
• Electron microscopy (cryo and regular) for structural and cell biology; Cathodoluminescence

EEO/Non‑Discrimination Commitment Statement

Harvard University is committed to equal opportunity and non‑discrimination. We seek talent from all parts of society and the world, and we strive to ensure everyone at Harvard thrives. Our differences help our community advance Harvard’s academic purposes. Harvard has an equal employment opportunity policy that outlines our commitment to prohibiting discrimination on the basis of race, ethnicity, color, national origin, sex, sexual orientation, gender identity, veteran status, religion, disability, or any other characteristic protected by law or identified in the university’s non‑discrimination policy. Harvard’s equal employment opportunity policy and non‑discrimination policy help all community members participate fully in work and campus life free from harassment and discrimination.