Postdoc: Orthopedic Infection Research Fellow

Mass General Brigham; Boston (MA); On-site; USD 72,000 - 81,000; Full time

Job summary

Massachusetts General Physicians Organization, Inc. invites applications for a full-time post-doctoral research fellow in the Harris Orthopaedics Laboratory at Mass General Brigham. The appointment focuses on polymeric and hybrid materials for orthopaedics, translational research, and antibacterial device development.

The ideal candidate holds a Ph.D. in Biological Sciences, Pharmaceutical Sciences or Biomedical Engineering with strong microbiology and molecular biology skills; experience with

Qualifications

• Ph.D. in Biological Sciences, Pharmaceutical Sciences or Biomedical Engineering.
• Strong background in Microbiology and Molecular Biology.
• Experience with host-pathogen studies and transcriptomics preferred.
• Familiarity with BSL2 lab safety practices.

Responsibilities

• Establish polymicrobial and monomicrobial cultures related to infections.
• Characterize bacteria using conventional and advanced techniques.
• Assess antibiotic resistance, tolerance and virulence.
• Establish cell cultures and perform molecular/biochemical assays.
• Molecular characterization of pathogens and host responses (DNA/RNA, Real-time PCR, RNA-Seq).
• Utilize advanced microscopy (fluorescence, confocal, live, SEM/TEM).
• Conduct bacterial transcriptomics and bioinformatic analyses.
• Study host-pathogen interactions in vitro and in vivo models.
• Perform drug susceptibility testing and antibacterial studies.
• Design in-vitro periprosthetic joint infection models for preclinical work.
• Supervise biomedical research engineers and collaborate on device formulation.
• Liaise with team members and collaborators for preclinical studies.

Skills

Microbiology of Staphylococcus aureus

Staphylococcus epidermidis

gram-negative bacteria

BSL2 lab safety practices

host-pathogen studies

transcriptomics

Education

Ph.D. in Biological Sciences

Ph.D. in Pharmaceutical Sciences

Ph.D. in Biomedical Engineering

Job description

Massachusetts General Physicians Organization, Inc. invites applications for a full-time post-doctoral research fellow in the Harris Orthopaedics Laboratory at Mass General Brigham. The appointment focuses on polymeric and hybrid materials for orthopaedics, translational research, and antibacterial device development.

The ideal candidate holds a Ph.D. in Biological Sciences, Pharmaceutical Sciences or Biomedical Engineering with strong microbiology and molecular biology skills; experience with