Postdoc: Long-Read Transcriptomics in Neurodegeneration

Office of Intramural Training & Education; Bethesda (MD); On-site; USD 65,000 - 90,000; Full time

Job summary

The Translational Neurogenetics Unit at NIH's National Institute on Aging (NIA) invites applications for a Postdoctoral Fellow in Long-Read Transcriptomics and Multi-Omics of Neurodegeneration. The role centers on building isoform-resolved maps from long-read RNA data and integrating proteomics, with potential wet-lab work.

The fellow will collaborate with Dr. Kimberley Billingsley and international partners to advance research on Alzheimer's disease and related dementias using Oxford Nanopore

Qualifications

• PhD in genomics, bioinformatics, computational biology, molecular biology or a related field.
• Fewer than 5 years of postdoctoral experience preferred.
• Experience analysing high-throughput sequencing data in Python or R, on Linux/HPC.

Responsibilities

• Lead projects combining long-read RNA sequencing, direct RNA sequencing and proteomics in human brain.
• Build isoform-resolved transcript maps and reinterpret existing genetic and short-read data.
• Study RNA modifications in disease and identify disease-relevant isoforms at the protein level.
• Collaborate with computational and wet-lab teams and international partners.

Skills

Python

R

Linux/HPC

Long-read sequencing

Education

PhD in genomics, bioinformatics, computational biology or related field

Tools

Oxford Nanopore

PacBio

Job description

The Translational Neurogenetics Unit at NIH's National Institute on Aging (NIA) invites applications for a Postdoctoral Fellow in Long-Read Transcriptomics and Multi-Omics of Neurodegeneration. The role centers on building isoform-resolved maps from long-read RNA data and integrating proteomics, with potential wet-lab work.

The fellow will collaborate with Dr. Kimberley Billingsley and international partners to advance research on Alzheimer's disease and related dementias using Oxford Nanopore