Postdoctoral Fellow Position at NIH

NIA; Baltimore (MD); Sur place; USD 65 000 - 90 000; Plein temps

Résumé du poste

The National Institute on Aging (NIA), part of the NIH, is inviting applications for a postdoctoral fellow to join the Laboratory of Genetics and Genomics in Baltimore, MD. The position focuses on a TOP3B complex involved in transcription and translation during neurodevelopment and aging, with multiple related projects in DNA damage response and genomic stability.

Qualified candidates will hold a Ph.D. in a relevant field, with up to five years of postdoctoral experience preferred.

Qualifications

• Ph.D. required in a related field.
• Postdoctoral experience up to five years preferred.
• Experience with RNA biology, genomics, and model organisms is desirable.

Responsabilités

• Carry out research on the TOP3B DNA/RNA dual-activity complex and related projects.
• Purify multi-protein complexes and analyze their structure and function.
• Contribute to studies on transcription regulation, neurodevelopment, and aging.

Connaissances

RNA biology

Genomics

Neuroscience

Epigenetics

Chromatin

Mouse models

Drosophila models

Formation

Ph.D. in a relevant field

Postdoctoral experience ≤5 years

Description du poste

The National Institute on Aging, a major research component of the National Institutes of Health (NIH) in the Department of Health and Human Services (DHHS) is recruiting one postdoctoral fellow to jointhe Laboratory of Genetics and Genomics, Intramural Research Program (IRP), with a background in any of the following areas: RNA biology, neuroscience, epigenetics, chromatin, genomics, and mouse or Drosophila models. The main project is to study a newly identified DNA/RNA dual-activity TOP3B topoisomerase complex that is crucial for regulating transcription and translation during neurodevelopment and preventing mental disorders, including schizophrenia, autism, and cognitive dysfunction (Xu et al., Nat. Neuroscience, 2013; Joo et al., Nat. Comm.2020; Su et al., NAR 2022; Lee et al., Cell Reports 2025). The complex also plays critical roles in stress response pathways and maintaining normal aging (Su et al., NAR 2023), and is a drug target for RNA viruses (Zhang et al., JBC 2025). Other projects include purification of multi-protein complexes, and analysis of their structures and functions in the response to DNA damage response and in diseases arising from genomic instability (Yan et al., Mol. Cell, 2010; Yan et al., Mol. Cell 2012; Xu et al., Genes & Dev. 2008; Meetei et al., Nat. Genet. 2003) (https://irp.nih.gov/pi/weidong-wang). Successful applicants should have a Ph.D. degree or equivalent, and no more than five years of postdoctoral research experience. Salary is commensurate with research experience and accomplishments.

DHHS and NIH are Equal Opportunity Employers. The NIH is dedicated to building a diverse community in its training and employment programs.

Employer Name: Laboratory of Genetics and Genomics, National Institute on Aging.

Position Location: The position is located in Baltimore, MD, a city with a stimulating scientific and cultural environment, with proximity to the Johns Hopkins medical campus.

Application Deadline: 12/7/2026.