Postdoc: Intravital Imaging & Lung Repair (3P Microscopy)

Yale School of Medicine - Department of Genetics; New Haven (CT); On-site; USD 60,000 - 75,000; Full time

Job summary

The Chioccioli Lab at Yale School of Medicine, Departments of Genetics and Comparative Medicine, seeks a highly motivated Postdoctoral Associate with hands-on experience in intravital imaging and imaging-window surgery to lead our in vivo imaging programme.

The successful candidate will lead in vivo imaging, track progenitor and tumour-initiating cells in lung and other organs, and be trained in lung-specific surgery and imaging.

Qualifications

• PhD, MD or MD/PhD in cell or developmental biology, cancer biology, stem cell biology, immunology, biophysics, biomedical engineering or a related field, completed or expected within 6 months
• Hands-on experience implanting chronic imaging windows in mice (e.g., abdominal, mammary, cranial, dorsal skinfold or thoracic)
• Experience with multiphoton (2P/3P) intravital microscopy, ideally longitudinal imaging over days to weeks
• Quantitative image analysis and cell tracking (e.g., Imaris, Fiji, Python or MATLAB)
• Strong communication skills and the ability to work both independently and in a team
• Preferred: intravital imaging of tumours, metastasis or tumour-immune interactions

Responsibilities

• Perform survival surgery to implant imaging windows (thoracic and abdominal) and carry out longitudinal 3-photon intravital imaging in lineage-traced mouse models of injury and tumour initiation
• Develop and optimise the imaging pipeline, including window design, motion correction, deep-tissue imaging and long-term re-registration of the same fields
• Quantify cell behaviours such as migration, division, fate transitions and tumour-immune interactions
• Integrate imaging results with lineage tracing, histology and single-nucleus multiome data
• Publish first-author papers, present at meetings, and train lab members in surgery and imaging
• Yale University is an Equal Opportunity/Affirmative Action employer

Skills

Intravital imaging

Imaging-window surgery

Multiphoton microscopy

Image analysis

Cell tracking

Communication

Education

PhD, MD or MD/PhD in life sciences

Tools

Imaris

Fiji

Python

MATLAB

Job description

The Chioccioli Lab at Yale School of Medicine, Departments of Genetics and Comparative Medicine, seeks a highly motivated Postdoctoral Associate with hands-on experience in intravital imaging and imaging-window surgery to lead our in vivo imaging programme.

The successful candidate will lead in vivo imaging, track progenitor and tumour-initiating cells in lung and other organs, and be trained in lung-specific surgery and imaging.