Postdoc: IDR Biochemistry & Structural Biology

Buck Institute for Research on Aging; Novato (CA); On-site; USD 74,000 - 81,000; Full time

Benefits offered by this job

Medical benefits

401(k) employer contribution

Paid time off

Parental leave

Job summary

The Buck Institute for Research on Aging in Novato, CA, invites applications for Postdoctoral Researchers to explore the structural and functional biology of intrinsically disordered proteins and regions (IDPs/IDRs). The role combines protein biochemistry with cutting-edge structural biology, biophysics, and computational modeling to map how sequence, mutations, and environment shape IDR ensembles.

Candidates will work with a multidisciplinary team to purify IDR-containing proteins, perform in

Qualifications

• Ph.D. in biochemistry, molecular biology, structural biology, chemical biology, biophysics, protein science, or a related discipline.
• Strong hands-on experience with recombinant protein expression, purification, and biochemical characterization.
• Demonstrated ability to independently troubleshoot experimental workflows.
• Strong quantitative and organizational skills.

Responsibilities

• Develop and optimize purification and sample-preparation workflows suitable for IDR-containing proteins for measurements including single-molecule profiling, HDX-MS, mass spectrometry, and other structural/biophysical assays
• Perform biochemical and biophysical characterization of purified proteins and assess sample quality, stability, oligomeric state, and conformational behavior
• Develop and perform in vitro assays examining IDR interactions, condensation, aggregation, and responses to candidate binders or small molecules
• Work with computational team members to interpret experimental results in the context of predicted conformational ensembles
• Maintain rigorous experimental records and contribute to milestone reports, manuscripts, presentations, and publications
• Help mentor research associates and junior laboratory members involved in the project

Skills

Protein expression

Protein purification

Biochemistry

Structural biology

Education

Ph.D. in biochemistry or related field

Tools

HDX-MS

Mass spectrometry

NMR

Cryo-EM

Job description

The Buck Institute for Research on Aging in Novato, CA, invites applications for Postdoctoral Researchers to explore the structural and functional biology of intrinsically disordered proteins and regions (IDPs/IDRs). The role combines protein biochemistry with cutting-edge structural biology, biophysics, and computational modeling to map how sequence, mutations, and environment shape IDR ensembles.

Candidates will work with a multidisciplinary team to purify IDR-containing proteins, perform in