Postdoc: Clonal Evolution & Genome Editing in Inherited BM

St. Jude Children's Research Hospital; Memphis (TN); On-site; USD 73,000 - 95,000; Full time

Benefits offered by this job

Competitive compensation

Relocation assistance

Career development support

Postdoc community

Job summary

St. Jude Children’s Research Hospital invites applications for a Postdoctoral Research Fellow in Memphis, TN, to study clonal evolution and leukemic transformation in inherited bone marrow failure disorders, focusing on Shwachman-Diamond syndrome.

The lab uses patient samples, iPSC models, CRISPR editing, and single-cell genomics, with a clinical bone marrow failure program access and strong collaborative environment.

Qualifications

• PhD, MD, or MD/PhD in hematology, cancer biology, genetics, genome engineering, immunology, or related field.
• Track record of productivity with at least one first-author publication.
• Hands-on experience with molecular and cell biology methods: mammalian cell culture, cloning, qPCR, flow cytometry, Western blot, scRNA-seq, basic biochemistry.
• Comfort with quantitative data analysis and clear scientific writing.
• Ability to work independently and collaboratively in a team.

Responsibilities

• Study mechanisms of clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, including SDS.
• Investigate somatic adaptation and how it shapes disease trajectory.
• Work with primary patient samples, iPSC models, CRISPR/base-editing screens, and single-cell genomics.

Skills

Mammalian cell culture

Cloning

qPCR

Flow cytometry

Western blot

Single-cell RNA-seq

Biochemistry

Scientific writing

Data analysis

Team collaboration

Education

PhD, MD, or MD/PhD (or expected within six months) in hematology, cancer biology, genetics, genome engineering, immunology

Tools

CRISPR/Cas9 editing

Base/Prime editing

NGS analysis

R

Python

Job description

St. Jude Children’s Research Hospital invites applications for a Postdoctoral Research Fellow in Memphis, TN, to study clonal evolution and leukemic transformation in inherited bone marrow failure disorders, focusing on Shwachman-Diamond syndrome.

The lab uses patient samples, iPSC models, CRISPR editing, and single-cell genomics, with a clinical bone marrow failure program access and strong collaborative environment.