Postdoc: Clonal Evolution & Genome Editing in BM Failure

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 62,000 - 83,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

St. Jude Children’s Research Hospital, Inc. invites applications for a postdoctoral research associate to study clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, focusing on Shwachman-Diamond syndrome. The Kennedy Lab leverages patient samples, iPSC models, CRISPR/base-editing screens and single-cell genomics.

The position provides access to a clinical bone marrow failure program and a collaborative, translational environment within Memphis, Tennessee.

Qualifications

• PhD, MD, or MD/PhD in hematology, cancer biology, genetics, genome engineering, immunology, or related field.
• First-author publication (published or in press).
• Hands-on experience with mammalian cell culture, cloning, qPCR, flow cytometry, Western blot, scRNA-seq, basic biochemistry.
• Quantitative data analysis and clear scientific writing.
• Able to work independently and with a team.
• Preferred: CRISPR/Cas9 or base/prime editing including guide design and outcome analysis.
• Primary hematopoietic stem/progenitor cell culture, CD34+ work, or xenotransplantation/murine models.
• NGS analysis experience (scRNA-seq, targeted sequencing, WES/WGS) and R/Python fluency.

Responsibilities

• Study clonal evolution and leukemic transformation in SDS using patient samples, iPSC models, CRISPR screens, and single-cell genomics.
• Work with a clinical bone marrow failure program and multidisciplinary teams.
• Analyze data and contribute to publications and presentations.
• Collaborate to translate findings toward therapeutic genome editing approaches.

Skills

Mammalian cell culture

Cloning

qPCR

Flow cytometry

Western blot

scRNA-seq

Single-cell genomics

CRISPR/Cas9 editing

Base editing / Prime editing

CD34+ hematopoietic cells

NGS data analysis (scRNA-seq/WES/WGS)

R / Python (data analysis)

First-author publication

Education

PhD, MD, or MD/PhD in hematology, cancer biology, genetics, genome engineering, immunology, or related field

Tools

CRISPR design tools

Job description

St. Jude Children’s Research Hospital, Inc. invites applications for a postdoctoral research associate to study clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, focusing on Shwachman-Diamond syndrome. The Kennedy Lab leverages patient samples, iPSC models, CRISPR/base-editing screens and single-cell genomics.

The position provides access to a clinical bone marrow failure program and a collaborative, translational environment within Memphis, Tennessee.