Post-doctoral Research Fellow, Center for Genomic Medicine

Massachusetts General Hospital; Boston (MA); On-site; USD 70,000 - 72,000; Full time

Job summary

Massachusetts General Hospital is seeking a highly motivated post-doctoral fellow in the Center for Genomic Medicine to study life-course epidemiology and multi-omics integration using large-scale EHR-based biobanks and longitudinal cohorts.

The successful candidate will work under senior investigators, contribute to data analysis across omics platforms, and collaborate with Harvard Medical School and the Broad Institute. Strong programming and English communication are required.

Qualifications

• Ph.D. in epidemiology, bioinformatics, biostatistics, computational biology, or related field; degree must be completed by start date.
• Priority for candidates with population-based research experience using phenotypic and/or multi-omics data from EHR, cohort studies, and/or biobanks.
• First author of one or more peer-reviewed publications and/or conference presentations.
• Experience with omics platforms (genetics, genomics, epigenetics, metabolomics, or proteomics) or interest in such research.
• Strong programming skills in R, Python, and/or SAS; excellent English verbal and written communication.

Responsibilities

• Lead research projects including life-course epidemiology and multi-omics integration.
• Work with clinical, genetic, and multi-omic data from large-scale EHR-based biobanks and cohorts.
• Collaborate across disciplines and mentor junior researchers.
• Develop and apply analytic methods to elucidate mechanisms linking exposures to disease risk.

Skills

R

Python

SAS

Omics data analysis

English communication

Independent researcher

Education

Ph.D. in epidemiology, bioinformatics, biostatistics, computational biology, or related field

MD

Job description

Site: The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

Dr. Jie (Jack) Hu and Dr. Richa Saxena in the Center for Genomic Medicine (CGM) at the Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), are seeking a highly motivated post-doctoral fellow candidate working in areas of life-course epidemiology, integrated omics, women's and children's health, and chronic disease prevention.

The fellow will work under direct mentorship of Dr. Jie (Jack) Hu, Instructor in the CGM and at MGH and HMS, Instructor in the Department of Epidemiology at Harvard T.H. Chan School of Public Health, and Associated Scientist at Broad Institute of MIT and Harvard.

Dr. Hu's research program focuses on investigating of how genetic, molecular, lifestyle, and environmental factors contribute to disease risk across the lifespan, with an emphasizes on adverse pregnancy outcomes, cardiometabolic diseases, and neurodegenerative disorders.

Applicants interested in life-course epidemiology, chronic disease epidemiology, large-scale electronic health records (EHR)-based datasets, genetics, metabolomics, proteomics, and multi-omics integration are encouraged to apply. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doc at the Harvard Medical School.

Principal Duties and Responsibilities

The fellow will be situated at MGH under the guidance and mentorship of Dr. Jie (Jack) Hu. The successful candidate will have opportunities to work with clinical, genetic, and multi-omic data from large-scale EHR-based biobanks (e.g., MGB Biobank, All of Us, etc.), pregnancy / birth cohorts (e.g., Boston Birth Cohort, TOPMed BCC-PREG and nuMoM2b-HHS studies, etc.), and longitudinal cohort studies (e.g., Nurses Health Studies, Women's Health Initiative, ROSMAP, TOPMed cohorts, etc.). The fellow will lead research projects including, but not limited to:

• Characterizing the risk of various chronic diseases among women with a history of adverse pregnancy outcomes, such as gestational diabetes and preeclampsia, using large-scale EHR-based biobanks and longitudinal cohort studies.
• Elucidating the biological mechanisms linking adverse pregnancy outcomes to an increased risk of future chronic diseases later in life through integrative multi-omics approaches - including genetics, epigenetics, metabolomics, and proteomics - in large-scale population-based studies.
• Identifying risk factors and underlying mechanisms related to the intergenerational transmission of chronic disease risk, including obesity and hypertension, by leveraging phenotypic and multi-omics data in pregnancy studies and birth cohorts.

Skills & Competencies Required

The ideal candidate will have received, or expect to receive soon, a Ph.D. in epidemiology, bioinformatics, biostatistics, computational biology, or a related field, or an M.D. The degree must be completed by the fellowship start date. Priority will be given to candidates with experience in conducting population-based research using phenotypic and/or multi-omics data from EHR, cohort studies, and/or biobanks. Additional qualifications include:

• First (or co-first) author of one or more peer-reviewed scientific publications and/or presentations at scientific conferences
• Experience in conducting research using one or more omics platforms (e.g., genetics, genomics, epigenetics, metabolomics, or proteomics), or interested in such research
• Strong programming skills in R, Python, and/or SAS
• Excellent English verbal and written communication skills
• Able to work both independently and in a collaborative and interdisciplinary research environment

Additional Job Details (if applicable)

The compensation range for this role is between $70,000-$71,500

Final compensation will be determined based on years of relevant experience, skills, and internal equity.

Remote Type

Onsite

Work Location

185 Cambridge Street

EEO Statement

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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